Liver Transplant Tolerance and Its Application to the Clinic: Can We Exploit the High Dose Effect?
Joint Authors
Bishop, G. Alex
Sharland, Alexandra F.
Cunningham, Eithne C.
Source
Journal of Immunology Research
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-06
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The tolerogenic properties of the liver have long been recognised, especially in regard to transplantation.
Spontaneous acceptance of liver grafts occurs in a number of experimental models and also in a proportion of clinical transplant recipients.
Liver graft acceptance results from donor antigen-specific tolerance, demonstrated by the extension of tolerance to other grafts of donor origin.
A number of factors have been proposed to be involved in liver transplant tolerance induction, including the release of soluble major histocompatibility (MHC) molecules from the liver, its complement of immunosuppressive donor leucocytes, and the ability of hepatocytes to directly interact with and destroy antigen-specific T cells.
The large tissue mass of the liver has also been suggested to act as a cytokine sink, with the potential to exhaust the immune response.
In this review, we outline the growing body of evidence, from experimental models and clinical transplantation, which supports a role for large tissue mass and high antigen dose in the induction of tolerance.
We also discuss a novel gene therapy approach to exploit this dose effect and induce antigen-specific tolerance robust enough to overcome a primed T cell memory response.
American Psychological Association (APA)
Cunningham, Eithne C.& Sharland, Alexandra F.& Bishop, G. Alex. 2013. Liver Transplant Tolerance and Its Application to the Clinic: Can We Exploit the High Dose Effect?. Journal of Immunology Research،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1006714
Modern Language Association (MLA)
Cunningham, Eithne C.…[et al.]. Liver Transplant Tolerance and Its Application to the Clinic: Can We Exploit the High Dose Effect?. Journal of Immunology Research No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-1006714
American Medical Association (AMA)
Cunningham, Eithne C.& Sharland, Alexandra F.& Bishop, G. Alex. Liver Transplant Tolerance and Its Application to the Clinic: Can We Exploit the High Dose Effect?. Journal of Immunology Research. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1006714
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1006714