Posttransplant Lymphoproliferative Disease after Lung Transplantation
Author
Source
Journal of Immunology Research
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-05
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Posttransplant lymphoproliferative disease (PTLD) after lung transplantation occurs due to immunosuppressant therapy which limits antiviral host immunity and permits Epstein-Barr viral (EBV) replication and transformation of B cells.
Mechanistically, EBV survives due to latency, escape from cytotoxic T cell responses, and downregulation of host immunity to EBV.
Clinical presentation of EBV may occur within the lung allograft early posttransplantation or later onset which is more likely to be disseminated.
Improvements in monitoring through EBV viral load have provided a means of earlier detection; yet, sensitivity and specificity of EBV load monitoring after lung transplantation may require further optimization.
Once PTLD develops, staging and tissue diagnosis are essential to appropriate histopathological classification, prognosis, and guidance for therapy.
The overall paradigm to treat PTLD has evolved over the past several years and depends upon assessment of risk such as EBV-naïve status, clinical presentation, and stage and sites of disease.
In general, clinical practice involves reduction in immunosuppression, anti-CD20 biologic therapy, and/or use of plasma cell inhibition, followed by chemotherapy for refractory PTLD.
This paper focuses upon the immunobiology of EBV and PTLD, as well as the clinical presentation, diagnosis, prognosis, and emerging treatments for PTLD after lung transplantation.
American Psychological Association (APA)
Neuringer, Isabel P.. 2013. Posttransplant Lymphoproliferative Disease after Lung Transplantation. Journal of Immunology Research،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-1006728
Modern Language Association (MLA)
Neuringer, Isabel P.. Posttransplant Lymphoproliferative Disease after Lung Transplantation. Journal of Immunology Research No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-1006728
American Medical Association (AMA)
Neuringer, Isabel P.. Posttransplant Lymphoproliferative Disease after Lung Transplantation. Journal of Immunology Research. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-1006728
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1006728