The Effect of Perioperative Immunonutrition on the Phagocytic Activity of Blood Platelets in Advanced Gastric Cancer Patients
Joint Authors
Matowicka Karna, Joanna
Kemona, Halina
Zareba, Konrad
Kamocki, Zbigniew
Kedra, Boguslaw
Gryko, Mariusz
Source
Journal of Immunology Research
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-28
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Background and Aims.
Perioperative immunonutrition can influence the phagocytic activity of platelets in advanced gastric cancer.
Methods.
51 patients with stage IV gastric cancer divided into four groups depending on the clinical status and 40 normal donors were analyzed.
Patients of groups I and II underwent palliative gastrectomy.
Patients of groups III and IV had exploratory laparotomy.
Perioperative immunonutrition was administered as follows: group I—TPN, II—oral arginine, peripheral TPN, III—TPN preoperatively, and IV—without nutrition.
The phagocytic activity of blood platelets was determined before and after nutritional therapy and was assessed by measuring the fraction of phagocytic thrombocytes (%phag) and the phagocytic index (Ixphag).
Results.
The percentage of phagocytizing platelets and the phagocytic index prior to and after the surgery amounted to the following: group I—1.136–1.237, P=NS, and 1.007–1.1, P=NS, respectively, II—1.111–1.25, P<0.05, and 1.011–1.083, P<0.05, III—1.112–1.186, P=NS, and 0.962–1.042, P=NS, and IV—1.085–0.96, P=NS, and 1.023–1.04, P=NS.
Conclusions.
The phagocytic activity of platelets in patients with advanced gastric cancer is significantly impaired.
Perioperative immunonutrition with oral arginine-rich diet can partially improve the phagocytic activity of blood platelets.
This trial is registred with Clinicaltrials.gov-NCT01704664.
American Psychological Association (APA)
Kamocki, Zbigniew& Matowicka Karna, Joanna& Gryko, Mariusz& Zareba, Konrad& Kedra, Boguslaw& Kemona, Halina. 2013. The Effect of Perioperative Immunonutrition on the Phagocytic Activity of Blood Platelets in Advanced Gastric Cancer Patients. Journal of Immunology Research،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1006730
Modern Language Association (MLA)
Kamocki, Zbigniew…[et al.]. The Effect of Perioperative Immunonutrition on the Phagocytic Activity of Blood Platelets in Advanced Gastric Cancer Patients. Journal of Immunology Research No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-1006730
American Medical Association (AMA)
Kamocki, Zbigniew& Matowicka Karna, Joanna& Gryko, Mariusz& Zareba, Konrad& Kedra, Boguslaw& Kemona, Halina. The Effect of Perioperative Immunonutrition on the Phagocytic Activity of Blood Platelets in Advanced Gastric Cancer Patients. Journal of Immunology Research. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1006730
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1006730