The Expression of Netrin-1 in the Thymus and Its Effects on Thymocyte Adhesion and Migration
Joint Authors
Guo, Xiao-Kai
Zhou, Yu
Zhang, Yu
Zhang, Jun
Qian, Xiao-Ping
Sun, Xiu-Yuan
Liu, Yuan-Feng
Source
Journal of Immunology Research
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-28
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Netrin-1, a known axon guidance molecule, being a secreted laminin-related molecule, has been suggested to be involved in multiple physiological and pathological conditions, such as organogenesis, angiogenesis, tumorigenesis, and inflammation-mediated tissue injury.
However, its function in thymocyte development is still unknown.
Here, we demonstrate that Netrin-1 is expressed in mouse thymus tissue and is primarily expressed in thymic stromal cells, and the expression of Netrin-1 in thymocytes can be induced by anti-CD3 antibody or IL-7 treatment.
Importantly, Netrin-1 mediates the adhesion of thymocytes, and this effect is comparable to or greater than that of fibronectin.
Furthermore, Netrin-1 specifically promotes the chemotaxis of CXCL12.
These suggest that Netrin-1 may play an important role in thymocyte development.
American Psychological Association (APA)
Guo, Xiao-Kai& Liu, Yuan-Feng& Zhou, Yu& Sun, Xiu-Yuan& Qian, Xiao-Ping& Zhang, Yu…[et al.]. 2013. The Expression of Netrin-1 in the Thymus and Its Effects on Thymocyte Adhesion and Migration. Journal of Immunology Research،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1006754
Modern Language Association (MLA)
Guo, Xiao-Kai…[et al.]. The Expression of Netrin-1 in the Thymus and Its Effects on Thymocyte Adhesion and Migration. Journal of Immunology Research No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-1006754
American Medical Association (AMA)
Guo, Xiao-Kai& Liu, Yuan-Feng& Zhou, Yu& Sun, Xiu-Yuan& Qian, Xiao-Ping& Zhang, Yu…[et al.]. The Expression of Netrin-1 in the Thymus and Its Effects on Thymocyte Adhesion and Migration. Journal of Immunology Research. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1006754
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1006754