Evidence for Prion-Like Mechanisms in Several Neurodegenerative Diseases: Potential Implications for Immunotherapy
Joint Authors
Marciniuk, Kristen
Taschuk, Ryan
Napper, Scott
Source
Journal of Immunology Research
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-20, 20 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-20
Country of Publication
Egypt
No. of Pages
20
Main Subjects
Abstract EN
Transmissible spongiform encephalopathies (TSEs) are fatal, untreatable neurodegenerative diseases.
While the impact of TSEs on human health is relatively minor, these diseases are having a major influence on how we view, and potentially treat, other more common neurodegenerative disorders.
Until recently, TSEs encapsulated a distinct category of neurodegenerative disorder, exclusive in their defining characteristic of infectivity.
It now appears that similar mechanisms of self-propagation may underlie other proteinopathies such as Alzheimer’s disease, Parkinson’s disease, Amyotrophic lateral sclerosis, and Huntington’s disease.
This link is of scientific interest and potential therapeutic importance as this route of self-propagation offers conceptual support and guidance for vaccine development efforts.
Specifically, the existence of a pathological, self-promoting isoform offers a rational vaccine target.
Here, we review the evidence of prion-like mechanisms within a number of common neurodegenerative disorders and speculate on potential implications and opportunities for vaccine development.
American Psychological Association (APA)
Marciniuk, Kristen& Taschuk, Ryan& Napper, Scott. 2013. Evidence for Prion-Like Mechanisms in Several Neurodegenerative Diseases: Potential Implications for Immunotherapy. Journal of Immunology Research،Vol. 2013, no. 2013, pp.1-20.
https://search.emarefa.net/detail/BIM-1006758
Modern Language Association (MLA)
Marciniuk, Kristen…[et al.]. Evidence for Prion-Like Mechanisms in Several Neurodegenerative Diseases: Potential Implications for Immunotherapy. Journal of Immunology Research No. 2013 (2013), pp.1-20.
https://search.emarefa.net/detail/BIM-1006758
American Medical Association (AMA)
Marciniuk, Kristen& Taschuk, Ryan& Napper, Scott. Evidence for Prion-Like Mechanisms in Several Neurodegenerative Diseases: Potential Implications for Immunotherapy. Journal of Immunology Research. 2013. Vol. 2013, no. 2013, pp.1-20.
https://search.emarefa.net/detail/BIM-1006758
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1006758