Heart Allograft Tolerance Induced and Maintained by Vascularized Hind-Limb Transplant in Rats
Joint Authors
Gorantla, Vijay S.
Wang, Yong
Zheng, Xin Xiao
Nakao, Atsunori
Liu, Quan
Zhang, Wensheng
Source
Journal of Immunology Research
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-12
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Organ/tissue transplantation has become an effective therapy for end-stage diseases.
However, immunosuppression after transplantation may cause severe side effects.
Donor-specific transplant tolerance was proposed to solve this problem.
In this study, we report a novel method for inducing and maintaining heart allograft tolerance rats.
First, we induced indefinite vascularized hind-limb allograft survival with a short-term antilymphocyte serum + Cyclosporine A treatment.
Peripheral blood chimerism disappeared 6-7 weeks after immunosuppression was withdrawn.
Then the recipients accepted secondary donor-strain skin and heart transplantation 200 days following vascularized hind-limb transplantation without any immunosuppression, but rejected third party skin allografts, a status of donor-specific tolerance.
The ELISPOT results suggested a mechanism of clone deletion.
These findings open new perspectives for the role of vascularized hind-limb transplant in the induction and maintenance of organ transplantation tolerance.
American Psychological Association (APA)
Liu, Quan& Wang, Yong& Nakao, Atsunori& Zhang, Wensheng& Gorantla, Vijay S.& Zheng, Xin Xiao. 2013. Heart Allograft Tolerance Induced and Maintained by Vascularized Hind-Limb Transplant in Rats. Journal of Immunology Research،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1006772
Modern Language Association (MLA)
Liu, Quan…[et al.]. Heart Allograft Tolerance Induced and Maintained by Vascularized Hind-Limb Transplant in Rats. Journal of Immunology Research No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-1006772
American Medical Association (AMA)
Liu, Quan& Wang, Yong& Nakao, Atsunori& Zhang, Wensheng& Gorantla, Vijay S.& Zheng, Xin Xiao. Heart Allograft Tolerance Induced and Maintained by Vascularized Hind-Limb Transplant in Rats. Journal of Immunology Research. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1006772
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1006772