Cytomegalovirus in the Neonate: Immune Correlates of Infection and Protection
Author
Source
Journal of Immunology Research
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-08-19
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Fetal and neonatal infections caused by human cytomegalovirus (CMV) are important causes of morbidity and occasional mortality.
Development of a vaccine against congenital CMV infection is a major public health priority.
Vaccine design is currently focused on strategies that aim to elicit neutralizing antibody and T-cell responses, toward the goal of preventing primary or recurrent infection in women of child-bearing age.
However, there has been relatively little attention given to understanding the mechanisms of immune protection against acquisition of CMV infection in the fetus and newborn and how this information might be exploited for vaccine design.
There has similarly been an insufficient study of what deficits in the immune response to CMV, both for mother and fetus, may increase susceptibility to congenital infection and disease.
Protection of the fetus against vertical transmission can likely be achieved by protection of the placenta, which has its own unique immunological milieu, further complicating the analysis of the correlates of protective immunity.
In this review, the current state of knowledge about immune effectors of protection against CMV in the maternal, placental, and fetal compartments is reviewed.
A better understanding of immune responses that prevent and/or predispose to infection will help in the development of novel vaccine strategies.
American Psychological Association (APA)
Schleiss, Mark R.. 2013. Cytomegalovirus in the Neonate: Immune Correlates of Infection and Protection. Journal of Immunology Research،Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-1006777
Modern Language Association (MLA)
Schleiss, Mark R.. Cytomegalovirus in the Neonate: Immune Correlates of Infection and Protection. Journal of Immunology Research No. 2013 (2013), pp.1-14.
https://search.emarefa.net/detail/BIM-1006777
American Medical Association (AMA)
Schleiss, Mark R.. Cytomegalovirus in the Neonate: Immune Correlates of Infection and Protection. Journal of Immunology Research. 2013. Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-1006777
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1006777