Epstein-Barr Virus in Systemic Autoimmune Diseases
Joint Authors
Duus, Karen
Draborg, Anette Holck
Houen, Gunnar
Source
Journal of Immunology Research
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-08-24
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Systemic autoimmune diseases (SADs) are a group of connective tissue diseases with diverse, yet overlapping, symptoms and autoantibody development.
The etiology behind SADs is not fully elucidated, but a number of genetic and environmental factors are known to influence the incidence of SADs.
Recent findings link dysregulation of Epstein-Barr virus (EBV) with SAD development.
EBV causes a persistent infection with a tight latency programme in memory B-cells, which enables evasion of the immune defence.
A number of immune escape mechanisms and immune-modulating proteins have been described for EBV.
These immune modulating functions make EBV a good candidate for initiation of autoimmune diseases and exacerbation of disease progression.
This review focuses on systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and Sjögren’s syndrome (SS) and sum up the existing data linking EBV with these diseases including elevated titres of EBV antibodies, reduced T-cell defence against EBV, and elevated EBV viral load.
Together, these data suggest that uncontrolled EBV infection can develop diverse autoreactivities in genetic susceptible individuals with different manifestations depending on the genetic background and the site of reactivation.
American Psychological Association (APA)
Draborg, Anette Holck& Duus, Karen& Houen, Gunnar. 2013. Epstein-Barr Virus in Systemic Autoimmune Diseases. Journal of Immunology Research،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1006790
Modern Language Association (MLA)
Draborg, Anette Holck…[et al.]. Epstein-Barr Virus in Systemic Autoimmune Diseases. Journal of Immunology Research No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-1006790
American Medical Association (AMA)
Draborg, Anette Holck& Duus, Karen& Houen, Gunnar. Epstein-Barr Virus in Systemic Autoimmune Diseases. Journal of Immunology Research. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1006790
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1006790