Potential of Immunoglobulin A to Prevent Allergic Asthma
Joint Authors
Gloudemans, Anouk K.
Lambrecht, Bart N.
Smits, Hermelijn H.
Source
Journal of Immunology Research
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-11
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Allergic asthma is characterized by bronchial hyperresponsiveness, a defective barrier function, and eosinophilic lower airway inflammation in response to allergens.
The inflammation is dominated by Th2 cells and IgE molecules and supplemented with Th17 cells in severe asthma.
In contrast, in healthy individuals, allergen-specific IgA and IgG4 molecules are found but no IgE, and their T cells fail to proliferate in response to allergens, probably because of the development of regulatory processes that actively suppress responses to allergens.
The presence of allergen-specific secretory IgA has drawn little attention so far, although a few epidemiological studies point at a reverse association between IgA levels and the incidence of allergic airway disease.
This review highlights the latest literature on the role of mucosal IgA in protection against allergic airway disease, the mechanisms described to induce secretory IgA, and the role of (mucosal) dendritic cells in this process.
Finally, we discuss how this information can be used to translate into the development of new therapies for allergic diseases based on, or supplemented with, IgA boosting strategies.
American Psychological Association (APA)
Gloudemans, Anouk K.& Lambrecht, Bart N.& Smits, Hermelijn H.. 2013. Potential of Immunoglobulin A to Prevent Allergic Asthma. Journal of Immunology Research،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-1006793
Modern Language Association (MLA)
Gloudemans, Anouk K.…[et al.]. Potential of Immunoglobulin A to Prevent Allergic Asthma. Journal of Immunology Research No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-1006793
American Medical Association (AMA)
Gloudemans, Anouk K.& Lambrecht, Bart N.& Smits, Hermelijn H.. Potential of Immunoglobulin A to Prevent Allergic Asthma. Journal of Immunology Research. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-1006793
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1006793