Persistent Suppression of Type 1 Diabetes by a Multicomponent Vaccine Containing a Cholera Toxin B Subunit-Autoantigen Fusion Protein and Complete Freund’s Adjuvant
Joint Authors
Fodor, István
Langridge, William H. R.
Dénes, Béla
Source
Journal of Immunology Research
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-11
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Data presented here demonstrate multifunctional vaccination strategies that harness vaccinia virus mediated delivery of a gene encoding an immunoenhanced diabetes autoantigen in combination with complete Freund’s adjuvant (CFA) that can maintain safe and durable immunologic homeostasis in NOD mice.
Systemic coinoculation of prediabetic mice with recombinant vaccinia virus rVV-CTB::GAD and undiluted or 10-fold diluted CFA demonstrated a significant decrease in hyperglycemia and pancreatic islet inflammation in comparison with control animals during 17–61 and 17–105 weeks of age, respectively.
Synergy in these beneficial effects was observed during 43–61 and 61–105 wks of age, respectively.
Inflammatory cytokine and chemokine levels in GAD-stimulated splenocytes isolated from vaccinated mice were generally lower than those detected in unvaccinated mice.
The overall health and humoral immune responses of the vaccinated animals remained normal throughout the duration of the experiments.
American Psychological Association (APA)
Dénes, Béla& Fodor, István& Langridge, William H. R.. 2013. Persistent Suppression of Type 1 Diabetes by a Multicomponent Vaccine Containing a Cholera Toxin B Subunit-Autoantigen Fusion Protein and Complete Freund’s Adjuvant. Journal of Immunology Research،Vol. 2013, no. 2013, pp.1-16.
https://search.emarefa.net/detail/BIM-1006806
Modern Language Association (MLA)
Dénes, Béla…[et al.]. Persistent Suppression of Type 1 Diabetes by a Multicomponent Vaccine Containing a Cholera Toxin B Subunit-Autoantigen Fusion Protein and Complete Freund’s Adjuvant. Journal of Immunology Research No. 2013 (2013), pp.1-16.
https://search.emarefa.net/detail/BIM-1006806
American Medical Association (AMA)
Dénes, Béla& Fodor, István& Langridge, William H. R.. Persistent Suppression of Type 1 Diabetes by a Multicomponent Vaccine Containing a Cholera Toxin B Subunit-Autoantigen Fusion Protein and Complete Freund’s Adjuvant. Journal of Immunology Research. 2013. Vol. 2013, no. 2013, pp.1-16.
https://search.emarefa.net/detail/BIM-1006806
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1006806