![](/images/graphics-bg.png)
T Helper 17 Cells in Autoimmune Liver Diseases
Joint Authors
Hiasa, Yoichi
Onji, Morikazu
Abe, Masanori
Source
Journal of Immunology Research
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-10
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Many autoimmune diseases are driven by self-reactive T helper (Th) cells.
A new population of effector CD4+ T cells characterized by the secretion of interleukin (IL)-17, referred to as Th17 cells, has been demonstrated to be phenotypically, functionally, and developmentally distinct from Th1 and Th2 cells.
Because the liver is known to be an important source of transforming growth factor-β and IL-6, which are cytokines that are crucial for Th17 differentiation, it is very likely that Th17 cells contribute to liver inflammation and autoimmunity.
In contrast, another distinct subset of T cells, regulatory T cells (Treg), downregulate immune responses and play an important role in maintaining self-tolerance.
In addition, there is a reciprocal relationship between Th17 cells and Tregs, in development and effector functions, and the balance between Th17 and Treg cells can affect the outcome of immune responses, particularly in autoimmune diseases.
In this review, we will focus on the latest investigative findings related to Th17 cells in autoimmune liver disease.
American Psychological Association (APA)
Abe, Masanori& Hiasa, Yoichi& Onji, Morikazu. 2013. T Helper 17 Cells in Autoimmune Liver Diseases. Journal of Immunology Research،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1006815
Modern Language Association (MLA)
Abe, Masanori…[et al.]. T Helper 17 Cells in Autoimmune Liver Diseases. Journal of Immunology Research No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-1006815
American Medical Association (AMA)
Abe, Masanori& Hiasa, Yoichi& Onji, Morikazu. T Helper 17 Cells in Autoimmune Liver Diseases. Journal of Immunology Research. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1006815
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1006815