Microglial Dysregulation in Psychiatric Disease
Joint Authors
Pittenger, Christopher
Frick, Luciana Romina
Williams, Kyle
Source
Journal of Immunology Research
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-18
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Microglia, the brain's resident immune cells, are phagocytes of the macrophage lineage that have a key role in responding to inflammation and immune challenge in the brain.
More recently, they have been shown to have a number of important roles beyond immune surveillance and response, including synaptic pruning during development and the support of adult neurogenesis.
Microglial abnormalities have been found in several neuropsychiatric conditions, though in most cases it remains unclear whether these are causative or are a reaction to some other underlying pathophysiology.
Here we summarize postmortem, animal, neuroimaging, and other evidence for microglial pathology in major depression, schizophrenia, autism, obsessive-compulsive disorder, and Tourette syndrome.
We identify gaps in the existing literature and important areas for future research.
If microglial pathology proves to be an important causative factor in these or other neuropsychiatric diseases, modulators of microglial function may represent a novel therapeutic strategy.
American Psychological Association (APA)
Frick, Luciana Romina& Williams, Kyle& Pittenger, Christopher. 2013. Microglial Dysregulation in Psychiatric Disease. Journal of Immunology Research،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1006817
Modern Language Association (MLA)
Frick, Luciana Romina…[et al.]. Microglial Dysregulation in Psychiatric Disease. Journal of Immunology Research No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-1006817
American Medical Association (AMA)
Frick, Luciana Romina& Williams, Kyle& Pittenger, Christopher. Microglial Dysregulation in Psychiatric Disease. Journal of Immunology Research. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1006817
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1006817