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Regulatory T Cells in Allogeneic Stem Cell Transplantation
Joint Authors
Shimoni, Avichai
Nagler, Arnon
Michael, Maria
Source
Journal of Immunology Research
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-05-08
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Growing evidence suggests that cellular adoptive immunotherapy is becoming an attractive though challenging approach in regulating tumor immunity and alloresponses in clinical transplantation.
Naturally arising CD4+CD25+Foxp3+ regulatory T cells (Treg) have emerged as a key component in this regard.
Over the last decade, a large body of evidence from preclinical models has demonstrated their crucial role in auto- and tumor immunity and has opened the door to their “first-in-man” clinical application.
Initial studies in clinical allogeneic stem cell transplantation are very encouraging and may pave the way for other applications.
Further improvements in Treg ex vivo or in vivo expansion technologies will simplify their global clinical application.
In this review, we discuss the current knowledge of Treg biology and their potential for cell-based immunotherapy in allogeneic stem cell transplantation.
American Psychological Association (APA)
Michael, Maria& Shimoni, Avichai& Nagler, Arnon. 2013. Regulatory T Cells in Allogeneic Stem Cell Transplantation. Journal of Immunology Research،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1006818
Modern Language Association (MLA)
Michael, Maria…[et al.]. Regulatory T Cells in Allogeneic Stem Cell Transplantation. Journal of Immunology Research No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-1006818
American Medical Association (AMA)
Michael, Maria& Shimoni, Avichai& Nagler, Arnon. Regulatory T Cells in Allogeneic Stem Cell Transplantation. Journal of Immunology Research. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1006818
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1006818