Th17-Associated Cytokines as a Therapeutic Target for Steroid-Insensitive Asthma
Joint Authors
Ohtsuka, Shigeo
Ano, Satoshi
Ishii, Yukio
Matsuyama, Masashi
Kawaguchi, Mio
Hizawa, Nobuyuki
Morishima, Yuko
Source
Journal of Immunology Research
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-23
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Steroid-insensitive asthma is an infrequent but problematic airway disease that presents with persistent symptoms, airflow limitation, or recurrent exacerbations even when treated with steroid-based therapies.
Because of unsatisfactory results obtained from currently available therapies for steroid-insensitive asthma, a better understanding of its pathogenesis and the development of new targeted molecular therapies are warranted.
Recent studies indicated that levels of interleukin (IL)-17 are increased and both eosinophils and neutrophils infiltrate the airways of severe asthmatics.
IL-17 is a proinflammatory cytokine mainly secreted from helper T (Th) 17 cells and is important for the induction of neutrophil recruitment and migration at sites of inflammation.
This review focuses on the pathogenetic role of Th17 cells and their associated cytokines in steroid-insensitive asthma and discusses the prospects of novel therapeutic options targeting the Th17 signaling pathway.
American Psychological Association (APA)
Morishima, Yuko& Ano, Satoshi& Ishii, Yukio& Ohtsuka, Shigeo& Matsuyama, Masashi& Kawaguchi, Mio…[et al.]. 2013. Th17-Associated Cytokines as a Therapeutic Target for Steroid-Insensitive Asthma. Journal of Immunology Research،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1006819
Modern Language Association (MLA)
Morishima, Yuko…[et al.]. Th17-Associated Cytokines as a Therapeutic Target for Steroid-Insensitive Asthma. Journal of Immunology Research No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-1006819
American Medical Association (AMA)
Morishima, Yuko& Ano, Satoshi& Ishii, Yukio& Ohtsuka, Shigeo& Matsuyama, Masashi& Kawaguchi, Mio…[et al.]. Th17-Associated Cytokines as a Therapeutic Target for Steroid-Insensitive Asthma. Journal of Immunology Research. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1006819
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1006819