Expression and Function of the Homeostatic Molecule Del-1 in Endothelial Cells and the Periodontal Tissue
Joint Authors
Hosur, Kavita B.
Pyaram, Kalyani
Jotwani, Ravi
Liang, Shuang
Chavakis, Triantafyllos
Hajishengallis, George
Shin, Jieun
Source
Journal of Immunology Research
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-12
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Developmental endothelial locus-1 (Del-1) is an endothelial cell-secreted protein that limits the recruitment of neutrophils by antagonizing the interaction between the LFA-1 integrin on neutrophils and the intercellular adhesion molecule (ICAM)-1 on endothelial cells.
Mice with genetic or age-associated Del-1 deficiency exhibit increased neutrophil infiltration in the periodontium resulting in inflammatory bone loss.
Here we investigated additional novel mechanisms whereby Del-1 could interfere with neutrophil recruitment and inflammation.
Treatment of human endothelial cells with Del-1 did not affect the expression of endothelial molecules involved in the leukocyte adhesion cascade (ICAM-1, VCAM-1, and E-selectin).
Moreover, genetic or age-associated Del-1 deficiency did not significantly alter the expression of these adhesion molecules in the murine periodontium, further ruling out altered adhesion molecule expression as a mechanism whereby Del-1 regulates leukocyte recruitment.
Strikingly, Del-1 inhibited ICAM-1-dependent chemokine release (CXCL2, CCL3) by neutrophils.
Therefore, Del-1 could potentially suppress the amplification of inflammatory cell recruitment mediated through chemokine release by infiltrating neutrophils.
Interestingly, Del-1 was itself regulated by inflammatory stimuli, which generally exerted opposite effects on adhesion molecule expression.
The reciprocal regulation between Del-1 and inflammation may contribute to optimally balance the protective and the potentially harmful effects of inflammatory cell recruitment.
American Psychological Association (APA)
Shin, Jieun& Hosur, Kavita B.& Pyaram, Kalyani& Jotwani, Ravi& Liang, Shuang& Chavakis, Triantafyllos…[et al.]. 2013. Expression and Function of the Homeostatic Molecule Del-1 in Endothelial Cells and the Periodontal Tissue. Journal of Immunology Research،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-1006821
Modern Language Association (MLA)
Shin, Jieun…[et al.]. Expression and Function of the Homeostatic Molecule Del-1 in Endothelial Cells and the Periodontal Tissue. Journal of Immunology Research No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-1006821
American Medical Association (AMA)
Shin, Jieun& Hosur, Kavita B.& Pyaram, Kalyani& Jotwani, Ravi& Liang, Shuang& Chavakis, Triantafyllos…[et al.]. Expression and Function of the Homeostatic Molecule Del-1 in Endothelial Cells and the Periodontal Tissue. Journal of Immunology Research. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-1006821
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1006821