Efficacy of Abatacept for Arthritis in Patients with an Overlap Syndrome between Rheumatoid Arthritis and Systemic Lupus Erythematosus
Joint Authors
Yamagata, Mieko
Takabayashi, Katsuhiko
Ikeda, Kei
Makita, Sohei
Nakajima, Hiroshi
Hosokawa, Junichi
Nakagomi, Daiki
Sanayama, Yoshie
Source
Journal of Immunology Research
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-14
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
This study aimed to investigate the efficacy of abatacept for arthritis in patients with rhupus, an overlap syndrome between rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE).
Methods.
Patients who fulfilled both the 2010 ACR/EULAR criteria for RA classification and the 1997 ACR revised criteria for classification of SLE and received abatacept treatment for arthritis were retrospectively studied.
Results.
Six rhupus patients who fulfilled the inclusion criteria above were identified.
All patients had active arthritis despite receiving antirheumatic drugs including methotrexate when abatacept was initiated.
Clinical Disease Activity Index (CDAI) significantly decreased between baseline and 12 weeks (P=0.028) and remained low through 24 weeks.
All patients achieved either a good or moderate response according to the EULAR response criteria at 24 weeks.
Health Assessment Questionnaire-Disability Index (HAQ-DI) also significantly decreased between baseline and 24 weeks (P=0.043).
In addition, the levels of immunoglobulin G and anti-DNA antibody significantly decreased between baseline and 24 weeks (P=0.028 and P=0.043, resp.).
Conclusions.
Treatment with abatacept is likely to be efficacious in patients with rhupus whose arthritis is refractory to methotrexate.
In addition, abatacept may have a moderate effect on abnormal antibody production in rhupus patients.
American Psychological Association (APA)
Ikeda, Kei& Sanayama, Yoshie& Makita, Sohei& Hosokawa, Junichi& Yamagata, Mieko& Nakagomi, Daiki…[et al.]. 2013. Efficacy of Abatacept for Arthritis in Patients with an Overlap Syndrome between Rheumatoid Arthritis and Systemic Lupus Erythematosus. Journal of Immunology Research،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1006858
Modern Language Association (MLA)
Ikeda, Kei…[et al.]. Efficacy of Abatacept for Arthritis in Patients with an Overlap Syndrome between Rheumatoid Arthritis and Systemic Lupus Erythematosus. Journal of Immunology Research No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-1006858
American Medical Association (AMA)
Ikeda, Kei& Sanayama, Yoshie& Makita, Sohei& Hosokawa, Junichi& Yamagata, Mieko& Nakagomi, Daiki…[et al.]. Efficacy of Abatacept for Arthritis in Patients with an Overlap Syndrome between Rheumatoid Arthritis and Systemic Lupus Erythematosus. Journal of Immunology Research. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1006858
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1006858