Chronic Deep Brain Stimulation of the Hypothalamic Nucleus in Wistar Rats Alters Circulatory Levels of Corticosterone and Proinflammatory Cytokines
Joint Authors
De La Cruz-Aguilera, Dora Luz
Velasco-Velázquez, Marco Antonio
Calleja-Castillo, Juan Manuel
Manjarrez, Joaquín
Hernández, María Eugenia
Aguirre-Cruz, Lucinda
Morales-Espinoza, Gabriel
Pavon, Lenin
Moreno-Aguilar, Julia
Source
Journal of Immunology Research
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-23
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Deep brain stimulation (DBS) is a therapeutic option for several diseases, but its effects on HPA axis activity and systemic inflammation are unknown.
This study aimed to detect circulatory variations of corticosterone and cytokines levels in Wistar rats, after 21 days of DBS-at the ventrolateral part of the ventromedial hypothalamic nucleus (VMHvl), unilateral cervical vagotomy (UCVgX), or UCVgX plus DBS.
We included the respective control (C) and sham (S) groups (n=6 rats per group).
DBS treated rats had higher levels of TNF-α (120%; P<0.01) and IFN-γ (305%; P<0.001) but lower corticosterone concentration (48%; P<0.001) than C and S.
UCVgX animals showed increased corticosterone levels (154%; P<0.001) versus C and S.
UCVgX plus DBS increased IL-1β (402%; P<0.001), IL-6 (160%; P<0.001), and corsticosterone (178%; P<0.001 versus 48%; P<0.001) compared with the C and S groups.
Chronic DBS at VMHvl induced a systemic inflammatory response accompanied by a decrease of HPA axis function.
UCVgX rats experienced HPA axis hyperactivity as result of vagus nerve injury; however, DBS was unable to block the HPA axis hyperactivity induced by unilateral cervical vagotomy.
Further studies are necessary to explore these findings and their clinical implication.
American Psychological Association (APA)
Calleja-Castillo, Juan Manuel& De La Cruz-Aguilera, Dora Luz& Manjarrez, Joaquín& Velasco-Velázquez, Marco Antonio& Morales-Espinoza, Gabriel& Moreno-Aguilar, Julia…[et al.]. 2013. Chronic Deep Brain Stimulation of the Hypothalamic Nucleus in Wistar Rats Alters Circulatory Levels of Corticosterone and Proinflammatory Cytokines. Journal of Immunology Research،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1006859
Modern Language Association (MLA)
Calleja-Castillo, Juan Manuel…[et al.]. Chronic Deep Brain Stimulation of the Hypothalamic Nucleus in Wistar Rats Alters Circulatory Levels of Corticosterone and Proinflammatory Cytokines. Journal of Immunology Research No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-1006859
American Medical Association (AMA)
Calleja-Castillo, Juan Manuel& De La Cruz-Aguilera, Dora Luz& Manjarrez, Joaquín& Velasco-Velázquez, Marco Antonio& Morales-Espinoza, Gabriel& Moreno-Aguilar, Julia…[et al.]. Chronic Deep Brain Stimulation of the Hypothalamic Nucleus in Wistar Rats Alters Circulatory Levels of Corticosterone and Proinflammatory Cytokines. Journal of Immunology Research. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1006859
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1006859