Targeting BCL2 Family in Human Myeloid Dendritic Cells: A Challenge to Cure Diseases with Chronic Inflammations Associated with Bone Loss
Joint Authors
Henter, Jan-Inge
Valentin, Hélène
Ismail, Mohamad Bachar
Delprat, Christine
Olsson Åkefeldt, Selma
Aricò, Maurizio
Source
Journal of Immunology Research
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-05-21
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Rheumatoid arthritis (RA) and Langerhans cell histiocytosis (LCH) are common and rare diseases, respectively.
They associate myeloid cell recruitment and survival in inflammatory conditions with tissue destruction and bone resorption.
Manipulating dendritic cell (DC), and, especially, regulating their half-life and fusion, is a challenge.
Indeed, these myeloid cells display pathogenic roles in both diseases and may be an important source of precursors for differentiation of osteoclasts, the bone-resorbing multinucleated giant cells.
We have recently documented that the proinflammatory cytokine IL-17A regulates long-term survival of DC by inducing BCL2A1 expression, in addition to the constitutive MCL1 expression.
We summarize bibliography of the BCL2 family members and their therapeutic targeting, with a special emphasis on MCL1 and BCL2A1, discussing their potential impact on RA and LCH.
Our recent knowledge in the survival pathway, which is activated to perform DC fusion in the presence of IL-17A, suggests that targeting MCL1 and BCL2A1 in infiltrating DC may affect the clinical outcomes in RA and LCH.
The development of new therapies, interfering with MCL1 and BCL2A1 expression, to target long-term surviving inflammatory DC should be translated into preclinical studies with the aim to increase the well-being of patients with RA and LCH.
American Psychological Association (APA)
Olsson Åkefeldt, Selma& Ismail, Mohamad Bachar& Valentin, Hélène& Aricò, Maurizio& Henter, Jan-Inge& Delprat, Christine. 2013. Targeting BCL2 Family in Human Myeloid Dendritic Cells: A Challenge to Cure Diseases with Chronic Inflammations Associated with Bone Loss. Journal of Immunology Research،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-1006860
Modern Language Association (MLA)
Olsson Åkefeldt, Selma…[et al.]. Targeting BCL2 Family in Human Myeloid Dendritic Cells: A Challenge to Cure Diseases with Chronic Inflammations Associated with Bone Loss. Journal of Immunology Research No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-1006860
American Medical Association (AMA)
Olsson Åkefeldt, Selma& Ismail, Mohamad Bachar& Valentin, Hélène& Aricò, Maurizio& Henter, Jan-Inge& Delprat, Christine. Targeting BCL2 Family in Human Myeloid Dendritic Cells: A Challenge to Cure Diseases with Chronic Inflammations Associated with Bone Loss. Journal of Immunology Research. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-1006860
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1006860