Neuroendocrine Immunoregulation in Multiple Sclerosis
Joint Authors
Lee, Wai-Ping
Deckx, Nathalie
Cools, Nathalie
Berneman, Zwi N.
Source
Journal of Immunology Research
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-23, 23 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-08
Country of Publication
Egypt
No. of Pages
23
Main Subjects
Abstract EN
Currently, it is generally accepted that multiple sclerosis (MS) is a complex multifactorial disease involving genetic and environmental factors affecting the autoreactive immune responses that lead to damage of myelin.
In this respect, intrinsic or extrinsic factors such as emotional, psychological, traumatic, or inflammatory stress as well as a variety of other lifestyle interventions can influence the neuroendocrine system.
On its turn, it has been demonstrated that the neuroendocrine system has immunomodulatory potential.
Moreover, the neuroendocrine and immune systems communicate bidirectionally via shared receptors and shared messenger molecules, variously called hormones, neurotransmitters, or cytokines.
Discrepancies at any level can therefore lead to changes in susceptibility and to severity of several autoimmune and inflammatory diseases.
Here we provide an overview of the complex system of crosstalk between the neuroendocrine and immune system as well as reported dysfunctions involved in the pathogenesis of autoimmunity, including MS.
Finally, possible strategies to intervene with the neuroendocrine-immune system for MS patient management will be discussed.
Ultimately, a better understanding of the interactions between the neuroendocrine system and the immune system can open up new therapeutic approaches for the treatment of MS as well as other autoimmune diseases.
American Psychological Association (APA)
Deckx, Nathalie& Lee, Wai-Ping& Berneman, Zwi N.& Cools, Nathalie. 2013. Neuroendocrine Immunoregulation in Multiple Sclerosis. Journal of Immunology Research،Vol. 2013, no. 2013, pp.1-23.
https://search.emarefa.net/detail/BIM-1006862
Modern Language Association (MLA)
Deckx, Nathalie…[et al.]. Neuroendocrine Immunoregulation in Multiple Sclerosis. Journal of Immunology Research No. 2013 (2013), pp.1-23.
https://search.emarefa.net/detail/BIM-1006862
American Medical Association (AMA)
Deckx, Nathalie& Lee, Wai-Ping& Berneman, Zwi N.& Cools, Nathalie. Neuroendocrine Immunoregulation in Multiple Sclerosis. Journal of Immunology Research. 2013. Vol. 2013, no. 2013, pp.1-23.
https://search.emarefa.net/detail/BIM-1006862
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1006862