New Insights into the Role of the Immune Microenvironment in Breast Carcinoma
Joint Authors
Brugal Molina, Javier
de la Cruz-Merino, Luis
Alba Conejo, Emilio
Nogales Fernández, Esteban
Ruiz Borrego, Manuel
Codes Manuel de Villena, Manuel
Barco-Sánchez, Antonio
Henao Carrasco, Fernando
Nieto-García, Adoración
Grueso López, Ana
Sánchez-Margalet, Víctor
Ibáñez Martínez, José
Martínez Peinado, Antonio
Casares Lagar, Noelia
Vallejo Benítez, Ana
Source
Journal of Immunology Research
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-03
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Recently, immune edition has been recognized as a new hallmark of cancer.
In this respect, some clinical trials in breast cancer have reported imppressive outcomes related to laboratory immune findings, especially in the neoadjuvant and metastatic setting.
Infiltration by tumor infiltrating lymphocytes (TIL) and their subtypes, tumor-associated macrophages (TAM) and myeloid-derived suppressive cells (MDSC) seem bona fide prognostic and even predictive biomarkers, that will eventually be incorporated into diagnostic and therapeutic algorithms of breast cancer.
In addition, the complex interaction of costimulatory and coinhibitory molecules on the immune synapse and the different signals that they may exert represent another exciting field to explore.
In this review we try to summarize and elucidate these new concepts and knowledge from a translational perspective focusing on breast cancer, paying special attention to those aspects that might have more significance in clinical practice and could be useful to design successful therapeutic strategies in the future.
American Psychological Association (APA)
de la Cruz-Merino, Luis& Barco-Sánchez, Antonio& Henao Carrasco, Fernando& Nogales Fernández, Esteban& Vallejo Benítez, Ana& Brugal Molina, Javier…[et al.]. 2013. New Insights into the Role of the Immune Microenvironment in Breast Carcinoma. Journal of Immunology Research،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-1006922
Modern Language Association (MLA)
de la Cruz-Merino, Luis…[et al.]. New Insights into the Role of the Immune Microenvironment in Breast Carcinoma. Journal of Immunology Research No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-1006922
American Medical Association (AMA)
de la Cruz-Merino, Luis& Barco-Sánchez, Antonio& Henao Carrasco, Fernando& Nogales Fernández, Esteban& Vallejo Benítez, Ana& Brugal Molina, Javier…[et al.]. New Insights into the Role of the Immune Microenvironment in Breast Carcinoma. Journal of Immunology Research. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-1006922
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1006922