Therapeutic Potential of Tolerogenic Dendritic Cells in IBD: From Animal Models to Clinical Application
Joint Authors
Benítez-Ribas, Daniel
Cabezón, Raquel
Source
Journal of Immunology Research
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-12
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The gut mucosa undergoes continuous antigenic exposure from food antigens, commensal flora derived ligands, and pathogens.
This constant stimulation results in controlled inflammatory responses that are effectively suppressed by multiple factors.
This tight regulation, necessary to maintain intestinal homeostasis, is affected during inflammatory bowel diseases (IBD) resulting in altered immune responses to harmless microorganisms.
Dendritic cells (DCs) are sentinels of immunity, located in peripheral and lymphoid tissues, which are essential for homeostasis of T cell-dependent immune responses.
The expression of a particular set of pathogen recognition receptors allows DCs to initiate immune responses.
However, in the absence of danger signals, different DC subsets can induce active tolerance by inducing regulatory T cells (Treg), inhibiting inflammatory T helper cell responses, or both.
Interestingly, several protocols to generate clinical grade tolerogenic DC (tol-DCs) in vitro have been described, opening the possibility to restore the intestinal homeostasis to bacterial flora by cellular therapy.
In this review, we discuss different DC subsets and their role in IBD.
Additionally, we will review preclinical studies performed in animal models while describing recent characterization of tol-DCs from Crohn’s disease patients for clinical application.
American Psychological Association (APA)
Cabezón, Raquel& Benítez-Ribas, Daniel. 2013. Therapeutic Potential of Tolerogenic Dendritic Cells in IBD: From Animal Models to Clinical Application. Journal of Immunology Research،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1006923
Modern Language Association (MLA)
Cabezón, Raquel& Benítez-Ribas, Daniel. Therapeutic Potential of Tolerogenic Dendritic Cells in IBD: From Animal Models to Clinical Application. Journal of Immunology Research No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-1006923
American Medical Association (AMA)
Cabezón, Raquel& Benítez-Ribas, Daniel. Therapeutic Potential of Tolerogenic Dendritic Cells in IBD: From Animal Models to Clinical Application. Journal of Immunology Research. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1006923
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1006923