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Posttransplant Lymphoproliferative Disease after Pediatric Solid Organ Transplantation
Joint Authors
Mynarek, Martin
Maecker-Kolhoff, Britta
Schober, Tilmann
Behrends, Uta
Source
Journal of Immunology Research
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-24
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Patients after solid organ transplantation (SOT) carry a substantially increased risk to develop malignant lymphomas.
This is in part due to the immunosuppression required to maintain the function of the organ graft.
Depending on the transplanted organ, up to 15% of pediatric transplant recipients acquire posttransplant lymphoproliferative disease (PTLD), and eventually 20% of those succumb to the disease.
Early diagnosis of PTLD is often hampered by the unspecific symptoms and the difficult differential diagnosis, which includes atypical infections as well as graft rejection.
Treatment of PTLD is limited by the high vulnerability towards antineoplastic chemotherapy in transplanted children.
However, new treatment strategies and especially the introduction of the monoclonal anti-CD20 antibody rituximab have dramatically improved outcomes of PTLD.
This review discusses risk factors for the development of PTLD in children, summarizes current approaches to therapy, and gives an outlook on developing new treatment modalities like targeted therapy with virus-specific T cells.
Finally, monitoring strategies are evaluated.
American Psychological Association (APA)
Mynarek, Martin& Schober, Tilmann& Behrends, Uta& Maecker-Kolhoff, Britta. 2013. Posttransplant Lymphoproliferative Disease after Pediatric Solid Organ Transplantation. Journal of Immunology Research،Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-1006940
Modern Language Association (MLA)
Mynarek, Martin…[et al.]. Posttransplant Lymphoproliferative Disease after Pediatric Solid Organ Transplantation. Journal of Immunology Research No. 2013 (2013), pp.1-14.
https://search.emarefa.net/detail/BIM-1006940
American Medical Association (AMA)
Mynarek, Martin& Schober, Tilmann& Behrends, Uta& Maecker-Kolhoff, Britta. Posttransplant Lymphoproliferative Disease after Pediatric Solid Organ Transplantation. Journal of Immunology Research. 2013. Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-1006940
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1006940