Anti-HLA and Anti-MICA Antibodies in Liver Transplant Recipients: Effect on Long-Term Graft Survival
Joint Authors
Żochowska, Dorota
Pączek, Leszek
Mucha, Krzysztof
Ciszek, Michał
Foroncewicz, Bartosz
Ziarkiewicz-Wróblewska, Bogna
Krawczyk, Marek
Source
Journal of Immunology Research
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-24
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Presence of anti-HLA antibodies has a well-known impact on kidney grafts survival; however their role in liver transplantation has not been fully elucidated.
We conducted a 7-year prospective study to show correlation between presence of anti-HLA and anti-MICA antibodies and liver graft survival.
Methods.
Blood samples from 123 liver transplant recipients were collected during patients routine visits.
Time from transplantation to blood sample collection was different for each patient.
Blood samples were tested for anti-HLA (separately class I and II) and MICA antibodies using Luminex assays.
Results.
There were 32 (26%) patients with positive anti-HLA and 37 (30%) with positive anti-MICA antibodies.
Graft loss occurred in 7 cases (23%) in anti-HLA positive group compared to 20 (22%) in anti-HLA negative group (P=ns) and in 8 cases (22%) in anti-MICA positive group but 19 (23%) in anti-MICA negative group (P=ns).
No correlations were detected between presence of antibodies and acute graft rejection (AGR).
Presence of any antibodies (anti-HLA or anti-MICA antibodies) correlated with late graft rejection (P=0.04).
Conclusion.
Presence of anti-HLA or anti-MICA had no impact on long-term liver graft survival; however, detection of any antibodies was correlated with episodes of late graft rejection.
American Psychological Association (APA)
Ciszek, Michał& Foroncewicz, Bartosz& Mucha, Krzysztof& Żochowska, Dorota& Ziarkiewicz-Wróblewska, Bogna& Krawczyk, Marek…[et al.]. 2013. Anti-HLA and Anti-MICA Antibodies in Liver Transplant Recipients: Effect on Long-Term Graft Survival. Journal of Immunology Research،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-1006948
Modern Language Association (MLA)
Ciszek, Michał…[et al.]. Anti-HLA and Anti-MICA Antibodies in Liver Transplant Recipients: Effect on Long-Term Graft Survival. Journal of Immunology Research No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-1006948
American Medical Association (AMA)
Ciszek, Michał& Foroncewicz, Bartosz& Mucha, Krzysztof& Żochowska, Dorota& Ziarkiewicz-Wróblewska, Bogna& Krawczyk, Marek…[et al.]. Anti-HLA and Anti-MICA Antibodies in Liver Transplant Recipients: Effect on Long-Term Graft Survival. Journal of Immunology Research. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-1006948
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1006948