IL-17A in Human Respiratory Diseases: Innate or Adaptive Immunity? Clinical Implications
Joint Authors
Dupont, Lieven J.
Bullens, Dominique M. A.
Decraene, Ann
Seys, Sven
Source
Journal of Immunology Research
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-01-17
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Since the discovery of IL-17 in 1995 as a T-cell cytokine, inducing IL-6 and IL-8 production by fibroblasts, and the report of a separate T-cell lineage producing IL-17(A), called Th17 cells, in 2005, the role of IL-17 has been studied in several inflammatory diseases.
By inducing IL-8 production and subsequent neutrophil attraction towards the site of inflammation, IL-17A can link adaptive and innate immune responses.
More specifically, its role in respiratory diseases has intensively been investigated.
We here review its role in human respiratory diseases and try to unravel the question whether IL-17A only provides a link between the adaptive and innate respiratory immunity or whether this cytokine might also be locally produced by innate immune cells.
We furthermore briefly discuss the possibility to reduce local IL-17A production as a treatment option for respiratory diseases.
American Psychological Association (APA)
Bullens, Dominique M. A.& Decraene, Ann& Seys, Sven& Dupont, Lieven J.. 2013. IL-17A in Human Respiratory Diseases: Innate or Adaptive Immunity? Clinical Implications. Journal of Immunology Research،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1006952
Modern Language Association (MLA)
Bullens, Dominique M. A.…[et al.]. IL-17A in Human Respiratory Diseases: Innate or Adaptive Immunity? Clinical Implications. Journal of Immunology Research No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-1006952
American Medical Association (AMA)
Bullens, Dominique M. A.& Decraene, Ann& Seys, Sven& Dupont, Lieven J.. IL-17A in Human Respiratory Diseases: Innate or Adaptive Immunity? Clinical Implications. Journal of Immunology Research. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1006952
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1006952