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Tumor Protective Activity of CD4+ but Not of CD8+ T Cells in DNA-Vaccinated Mice Challenged with bcr-abl-Transformed Cells
Joint Authors
Petráčková, Martina
Lučanský, Vincent
Vonka, Vladimír
Source
Journal of Immunology Research
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-21
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
In the recent past, it has repeatedly been reported that CD4 cells play an important role in the immunology of chronic myeloid leukaemia.
It was therefore of interest to test their activity in an animal model using bcr-abl-transformed cells.
BALB/c mice were four times immunized with a DNA vaccine carrying the bcr-abl fusion gene.
Two weeks after the last vaccine dose, the animals were challenged with syngeneic bcr-abl-transformed 12B1 cells which form solid tumors after subcutaneous administration.
At the time of challenge, animals were treated with antibodies against the CD8+ T cells or CD4+ T cells.
The efficacy of the depletion was monitored and found highly effective.
All nonimmunized animals developed tumors.
All animals untreated with the antibodies as well as those in which CD8+ T cells had been depleted, were fully protected against the challenge.
On the other hand, almost all mice treated with anti-CD4+ antibody developed tumors.
These results strongly suggested that the CD4+ T cells acted as effectors in the present system.
American Psychological Association (APA)
Petráčková, Martina& Lučanský, Vincent& Vonka, Vladimír. 2013. Tumor Protective Activity of CD4+ but Not of CD8+ T Cells in DNA-Vaccinated Mice Challenged with bcr-abl-Transformed Cells. Journal of Immunology Research،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-1007005
Modern Language Association (MLA)
Petráčková, Martina…[et al.]. Tumor Protective Activity of CD4+ but Not of CD8+ T Cells in DNA-Vaccinated Mice Challenged with bcr-abl-Transformed Cells. Journal of Immunology Research No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-1007005
American Medical Association (AMA)
Petráčková, Martina& Lučanský, Vincent& Vonka, Vladimír. Tumor Protective Activity of CD4+ but Not of CD8+ T Cells in DNA-Vaccinated Mice Challenged with bcr-abl-Transformed Cells. Journal of Immunology Research. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-1007005
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1007005