The Association of CD81 Polymorphisms with Alloimmunization in Sickle Cell Disease
Joint Authors
Rajagopal, Krishnamoorthy
Vukmanovic, Stanislav
Dewan, Ramita
Maury, Jacqueline
Luban, Naomi L. C.
Tatari-Calderone, Zohreh
Girot, Robert
Le Bouder, Gama P.
Lionnet, François
Lasserre, Jacqueline
Tamouza, Ryad
Source
Journal of Immunology Research
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-05-22
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The goal of the present work was to identify the candidate genetic markers predictive of alloimmunization in sickle cell disease (SCD).
Red blood cell (RBC) transfusion is indicated for acute treatment, prevention, and abrogation of some complications of SCD.
A well-known consequence of multiple RBC transfusions is alloimmunization.
Given that a subset of SCD patients develop multiple RBC allo-/autoantibodies, while others do not in a similar multiple transfusional setting, we investigated a possible genetic basis for alloimmunization.
Biomarker(s) which predicts (predict) susceptibility to alloimmunization could identify patients at risk before the onset of a transfusion program and thus may have important implications for clinical management.
In addition, such markers could shed light on the mechanism(s) underlying alloimmunization.
We genotyped 27 single nucleotide polymorphisms (SNPs) in the CD81, CHRNA10, and ARHG genes in two groups of SCD patients.
One group (35) of patients developed alloantibodies, and another (40) had no alloantibodies despite having received multiple transfusions.
Two SNPs in the CD81 gene, that encodes molecule involved in the signal modulation of B lymphocytes, show a strong association with alloimmunization.
If confirmed in prospective studies with larger cohorts, the two SNPs identified in this retrospective study could serve as predictive biomarkers for alloimmunization.
American Psychological Association (APA)
Tatari-Calderone, Zohreh& Tamouza, Ryad& Le Bouder, Gama P.& Dewan, Ramita& Luban, Naomi L. C.& Lasserre, Jacqueline…[et al.]. 2013. The Association of CD81 Polymorphisms with Alloimmunization in Sickle Cell Disease. Journal of Immunology Research،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1007012
Modern Language Association (MLA)
Tatari-Calderone, Zohreh…[et al.]. The Association of CD81 Polymorphisms with Alloimmunization in Sickle Cell Disease. Journal of Immunology Research No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-1007012
American Medical Association (AMA)
Tatari-Calderone, Zohreh& Tamouza, Ryad& Le Bouder, Gama P.& Dewan, Ramita& Luban, Naomi L. C.& Lasserre, Jacqueline…[et al.]. The Association of CD81 Polymorphisms with Alloimmunization in Sickle Cell Disease. Journal of Immunology Research. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1007012
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1007012