The Role of the Innate Immune System in Alzheimer’s Disease and Frontotemporal Lobar Degeneration: An Eye on Microglia
Joint Authors
Barone, Cinzia
Scarpini, Elio
Galimberti, Daniela
Ridolfi, Elisa
Source
Journal of Immunology Research
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-17
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
In the last few years, genetic and biomolecular mechanisms at the basis of Alzheimer’s disease (AD) and frontotemporal lobar degeneration (FTLD) have been unraveled.
A key role is played by microglia, which represent the immune effector cells in the central nervous system (CNS).
They are extremely sensitive to the environmental changes in the brain and are activated in response to several pathologic events within the CNS, including altered neuronal function, infection, injury, and inflammation.
While short-term microglial activity has generally a neuroprotective role, chronic activation has been implicated in the pathogenesis of neurodegenerative disorders, including AD and FTLD.
In this framework, the purpose of this review is to give an overview of clinical features, genetics, and novel discoveries on biomolecular pathogenic mechanisms at the basis of these two neurodegenerative diseases and to outline current evidence regarding the role played by activated microglia in their pathogenesis.
American Psychological Association (APA)
Ridolfi, Elisa& Barone, Cinzia& Scarpini, Elio& Galimberti, Daniela. 2013. The Role of the Innate Immune System in Alzheimer’s Disease and Frontotemporal Lobar Degeneration: An Eye on Microglia. Journal of Immunology Research،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-1007013
Modern Language Association (MLA)
Ridolfi, Elisa…[et al.]. The Role of the Innate Immune System in Alzheimer’s Disease and Frontotemporal Lobar Degeneration: An Eye on Microglia. Journal of Immunology Research No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-1007013
American Medical Association (AMA)
Ridolfi, Elisa& Barone, Cinzia& Scarpini, Elio& Galimberti, Daniela. The Role of the Innate Immune System in Alzheimer’s Disease and Frontotemporal Lobar Degeneration: An Eye on Microglia. Journal of Immunology Research. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-1007013
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1007013