An Elucidation of Neutrophil Functions against Mycobacterium tuberculosis Infection
Joint Authors
Lagman, Minette
Kassissa, Christine
Pandya, Shalin
Luong, Jennifer
Morris, Devin
Kim, John
Ly, Judy
Kasko, Sarah
Nguyen, Thien
Khurasany, Melissa
Chi, Po-Ting
Venketaraman, Vishwanath
Chu, Michael
Source
Journal of Immunology Research
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-07
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
We characterized the functions of neutrophils in response to Mycobacterium tuberculosis (M.
tb) infection, with particular reference to glutathione (GSH).
We examined the effects of GSH in improving the ability of neutrophils to control intracellular M.
tb infection.
Our findings indicate that increasing the intracellular levels of GSH with a liposomal formulation of GSH (L-GSH) resulted in reduction in the levels of free radicals and increased acidification of M.
tb containing phagosomes leading to the inhibition in the growth of M.
tb.
This inhibitory mechanism is dependent on the presence of TNF-α and IL-6.
Our studies demonstrate a novel regulatory mechanism adapted by the neutrophils to control M.
tb infection.
American Psychological Association (APA)
Morris, Devin& Nguyen, Thien& Kim, John& Kassissa, Christine& Khurasany, Melissa& Luong, Jennifer…[et al.]. 2013. An Elucidation of Neutrophil Functions against Mycobacterium tuberculosis Infection. Journal of Immunology Research،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-1007021
Modern Language Association (MLA)
Morris, Devin…[et al.]. An Elucidation of Neutrophil Functions against Mycobacterium tuberculosis Infection. Journal of Immunology Research No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-1007021
American Medical Association (AMA)
Morris, Devin& Nguyen, Thien& Kim, John& Kassissa, Christine& Khurasany, Melissa& Luong, Jennifer…[et al.]. An Elucidation of Neutrophil Functions against Mycobacterium tuberculosis Infection. Journal of Immunology Research. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-1007021
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1007021