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pH Responsive Self-Assembly of Cucurbit[7]urils and Polystyrene-Block-Polyvinylpyridine Micelles for Hydrophobic Drug Delivery
Joint Authors
Moosa, Basem A.
Mashat, Afnan
Li, Wengang
Fhayli, Karim
Khashab, Niveen M.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-19
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Polystyrene-block-polyvinylpyridine (PS-b-P4VP) polypseudorotaxanes with cucurbit[7]urils (CB[7]) were prepared from water soluble PS-b-P4VPH+ polymer and CB[7] in aqueous solution at room temperature.
At acidic and neutral pH, the pyridinium block of PS-b-P4VP is protonated (PS-b-P4VPH+) pushing CB[7] to preferably host the P4VP block.
At basic pH (pH 8), P4VP is not charged and thus is not able to strongly complex CB[7].
This phenomenon was verified further by monitoring the release of pyrene, a hydrophobic cargo model, from a PS-b-P4VPH+/CB[7] micellar membrane.
Release study of UV active pyrene from the membrane at different pH values revealed that the system is only operational under basic conditions and that the host-guest interaction of CB[7] with P4VPH+ significantly slows down cargo release.
American Psychological Association (APA)
Moosa, Basem A.& Mashat, Afnan& Li, Wengang& Fhayli, Karim& Khashab, Niveen M.. 2013. pH Responsive Self-Assembly of Cucurbit[7]urils and Polystyrene-Block-Polyvinylpyridine Micelles for Hydrophobic Drug Delivery. Journal of Nanomaterials،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1008124
Modern Language Association (MLA)
Moosa, Basem A.…[et al.]. pH Responsive Self-Assembly of Cucurbit[7]urils and Polystyrene-Block-Polyvinylpyridine Micelles for Hydrophobic Drug Delivery. Journal of Nanomaterials No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-1008124
American Medical Association (AMA)
Moosa, Basem A.& Mashat, Afnan& Li, Wengang& Fhayli, Karim& Khashab, Niveen M.. pH Responsive Self-Assembly of Cucurbit[7]urils and Polystyrene-Block-Polyvinylpyridine Micelles for Hydrophobic Drug Delivery. Journal of Nanomaterials. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1008124
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1008124