Preparation and Biological Properties of Platinum(II) Complex-Loaded Copolymer PLA-TPGS
Joint Authors
Phuong Thu, Ha
Thi Hong Tuyet, Phan
Thi Thu Trang, Mai
Hoai Nam, Nguyen
Thi Nhu Hieu, Truong
Quang Duong, Le
Thi Nhu Hang, Tran
Ha, Tran Thi Hong
Nghi, Do Huu
Huu Cuong, Le
Huong, Le Mai
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-05
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
A new nanodrug system containing bis(menthone thiosemicarbazonato) Platinum(II) complex (Pt-thiomen) encapsulated with the block copolymers polylactide-d-α-tocopheryl polyethylene glycol 1000 succinate (PLA-TPGS) was prepared by a modified solvent extraction/evaporation technique.
The characteristics of the nanoparticles including surface morphology, size distribution, structure, and biological activities such as antimicrobial and cytotoxic activities were in vitro investigated.
The spherical nanoparticles were around 50 nm in size with core-shell structure and narrow-size distribution.
The encapsulated Pt-thiomen can avoid interaction with proteins in the blood plasma.
The inhibitory activity of Pt-thiomen-loaded PLA-TPGS nanoparticles on the growth of some bacteria, fungi, and Hep-G2 cells suggests a possibility of developing PLA-TPGS-Pt-thiomen nanoparticles as one of the potential chemotherapeutic agents.
American Psychological Association (APA)
Phuong Thu, Ha& Thi Hong Tuyet, Phan& Thi Thu Trang, Mai& Hoai Nam, Nguyen& Thi Nhu Hieu, Truong& Quang Duong, Le…[et al.]. 2013. Preparation and Biological Properties of Platinum(II) Complex-Loaded Copolymer PLA-TPGS. Journal of Nanomaterials،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1008209
Modern Language Association (MLA)
Phuong Thu, Ha…[et al.]. Preparation and Biological Properties of Platinum(II) Complex-Loaded Copolymer PLA-TPGS. Journal of Nanomaterials No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-1008209
American Medical Association (AMA)
Phuong Thu, Ha& Thi Hong Tuyet, Phan& Thi Thu Trang, Mai& Hoai Nam, Nguyen& Thi Nhu Hieu, Truong& Quang Duong, Le…[et al.]. Preparation and Biological Properties of Platinum(II) Complex-Loaded Copolymer PLA-TPGS. Journal of Nanomaterials. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1008209
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1008209