In Vitro Biocompatibility of Electrospun ChitosanCollagen Scaffold
Joint Authors
Wang, Peiwei
Liu, Junli
Zhang, Teng
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-19
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Chitosan/collagen composite nanofibrous scaffold has been greatly concerned in recent years for its favorable physicochemical properties which mimic the native extracellular matrix (ECM) both morphologically and chemically.
In a previous study, we had successfully fabricated nanofibrous chitosan/collagen composite by electrospinning.
In the present study, we further investigate the biocompatibility of such chitosan/collagen composite nanofiber to be used as scaffolds in vascular tissue engineering.
The porcine iliac artery endothelial cells (PIECs) were employed for morphogenesis, attachment, proliferation, and phenotypic studies.
Four characteristic EC markers, including two types of cell adhesion molecules, one proliferation molecule (PCNA), and one function molecule (p53), were studied by semiquantitative RT-PCR.
Results showed that the chitosan/collagen composite nanofibrous scaffold could enhance the attachment, spreading, and proliferation of PIECs and preserve the EC phenotype.
Our work provides profound proofs for the applicable potency of scaffolds made from chitosan/collagen composite nanofiber to be used in vascular tissue engineering.
American Psychological Association (APA)
Wang, Peiwei& Liu, Junli& Zhang, Teng. 2013. In Vitro Biocompatibility of Electrospun ChitosanCollagen Scaffold. Journal of Nanomaterials،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1008413
Modern Language Association (MLA)
Wang, Peiwei…[et al.]. In Vitro Biocompatibility of Electrospun ChitosanCollagen Scaffold. Journal of Nanomaterials No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-1008413
American Medical Association (AMA)
Wang, Peiwei& Liu, Junli& Zhang, Teng. In Vitro Biocompatibility of Electrospun ChitosanCollagen Scaffold. Journal of Nanomaterials. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1008413
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1008413