Effect of RGD Peptide-Coated TiO2 Nanotubes on the Attachment, Proliferation, and Functionality of Bone-Related Cells
Joint Authors
Moon, Kyung-Suk
Oh, Seunghan
Lee, Seoung Hoon
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-08-04
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The purpose of this research was to characterize an Arg-Gly-Asp (RGD) peptide immobilized on TiO2 nanotubes.
In addition, we investigated the effects of the RGD peptide-coated TiO2 nanotubes on the cellular response, proliferation, and functionality of osteogenic-induced human mesenchymal stem cells (hMSCs), which are osteoclasts that have been induced by bone marrow macrophages.
The RGD peptide was grafted covalently onto the surface of TiO2 nanotubes based on the results of SEM, FT-IR, and XPS.
Furthermore, the RGD peptide promoted the initial attachment and proliferation of the hMSCs, regardless of the size of the TiO2 nanotubes.
However, the RGD peptide did not prominently affect the osteogenic functionality of the hMSCs because the peptide suppressed hMSC motility associated with osteogenic differentiation.
The result of an in vitro osteoclast test showed that the RGD peptide accelerated the initial attachment of preosteoclasts and the formation of mature osteoclasts, which could resorb the bone matrix.
Therefore, we believe that an RGD coating on TiO2 nanotubes synthesized on Ti implants might not offer significant acceleration of bone formation in vivo because osteoblasts and osteoclasts reside in the same compartment.
American Psychological Association (APA)
Oh, Seunghan& Moon, Kyung-Suk& Lee, Seoung Hoon. 2013. Effect of RGD Peptide-Coated TiO2 Nanotubes on the Attachment, Proliferation, and Functionality of Bone-Related Cells. Journal of Nanomaterials،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-1008417
Modern Language Association (MLA)
Oh, Seunghan…[et al.]. Effect of RGD Peptide-Coated TiO2 Nanotubes on the Attachment, Proliferation, and Functionality of Bone-Related Cells. Journal of Nanomaterials No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-1008417
American Medical Association (AMA)
Oh, Seunghan& Moon, Kyung-Suk& Lee, Seoung Hoon. Effect of RGD Peptide-Coated TiO2 Nanotubes on the Attachment, Proliferation, and Functionality of Bone-Related Cells. Journal of Nanomaterials. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-1008417
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1008417