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Disposition kinetics of difloxacin in normal and experimentally infected chickens with mycoplasma gallisepticum
Other Title(s)
حركية الازالة لــ(difloxacin) للدجاج العادي والمصاب بفطر ( mycoplasma gallisepticum) مخبرياً
Joint Authors
Abd al-Aziz, Majdi I.
al-Shadhili, K. A.
al-Shazli, K. A.
Source
Kafr El-Sheikh Veterinary Medical Journal
Issue
Vol. 3, Issue 1 (30 Apr. 2005), pp.97-114, 18 p.
Publisher
Kafr El-Sheikh University Faculty of Veterinary Medicine
Publication Date
2005-04-30
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Topics
Abstract EN
The pharmacokinetic properties of difloxacin were investigated follo-wing intravenous, intramuscular and oral administration of 10 mg/kg body weight, in non-infected and experimentally mycoplasma infected chickens.
Serum concentrations of difloxacin were assayed microbial-ogically after intravenous, intramuscular and oral administrations.
difl-oxacin residues were detected in chicken tissues following repeated oral administrations in non-infected and infected chickens.
Following a single intravenous injection, the serum difloxacin level was best approximated to follow a two-compartment open model.
The elimination half-life (t0.5?) was 4.58 + 0.008 h.
The volume of distri-bution at steady-state (Vdss) was 2.12 + 0.07 L/kg and the mean resid-ence time (MRT) was 3.91 + 0.07 h.
Following a single oral administration of 10 mg/kg b.wt difloxacin, the recorded results revealed that serum level of difloxacin was higher in infected chickens than non infected chickens.
Serum concentrations peaked one hour post-drug administration with half lifes of absorption (t0.5ab) of 0.48 + 0.02 and 0.37 + 0.02 hour in non infected and myc-oplasma infected chickens, respectively.
The extent of serum protein binding of difloxacin in non-infected chickens was 15.44 + 1.24%.
Systemic bioavailability after oral and intramuscular administration of difloxacin in non-infected chickens was 75.87 and 93.03%, respectively.
Following oral and intramuscular administration of 10 mg difloxacin / kg b.wt once daily for 5 consecutive days in infected and non infected chic-kens, the drug could be detected in all tested tissue up to 48 hours after last oral and intramuscular dose in non infected and infected chickens.
American Psychological Association (APA)
Abd al-Aziz, Majdi I.& al-Shadhili, K. A.& al-Shazli, K. A.. 2005. Disposition kinetics of difloxacin in normal and experimentally infected chickens with mycoplasma gallisepticum. Kafr El-Sheikh Veterinary Medical Journal،Vol. 3, no. 1, pp.97-114.
https://search.emarefa.net/detail/BIM-101142
Modern Language Association (MLA)
Abd al-Aziz, Majdi I.…[et al.]. Disposition kinetics of difloxacin in normal and experimentally infected chickens with mycoplasma gallisepticum. Kafr El-Sheikh Veterinary Medical Journal Vol. 3, no. 1 (2005), pp.97-114.
https://search.emarefa.net/detail/BIM-101142
American Medical Association (AMA)
Abd al-Aziz, Majdi I.& al-Shadhili, K. A.& al-Shazli, K. A.. Disposition kinetics of difloxacin in normal and experimentally infected chickens with mycoplasma gallisepticum. Kafr El-Sheikh Veterinary Medical Journal. 2005. Vol. 3, no. 1, pp.97-114.
https://search.emarefa.net/detail/BIM-101142
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 110-114
Record ID
BIM-101142