Water-Protein Interactions: The Secret of Protein Dynamics
Joint Authors
Martini, Silvia
Bonechi, Claudia
Foletti, Alberto
Rossi, Claudio
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-05-20
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Water-protein interactions help to maintain flexible conformation conditions which are required for multifunctional protein recognition processes.
The intimate relationship between the protein surface and hydration water can be analyzed by studying experimental water properties measured in protein systems in solution.
In particular, proteins in solution modify the structure and the dynamics of the bulk water at the solute-solvent interface.
The ordering effects of proteins on hydration water are extended for several angstroms.
In this paper we propose a method for analyzing the dynamical properties of the water molecules present in the hydration shells of proteins.
The approach is based on the analysis of the effects of protein-solvent interactions on water protons NMR relaxation parameters.
NMR relaxation parameters, especially the nonselective (R1NS ) and selective (R1SE ) spin-lattice relaxation rates of water protons, are useful for investigating the solvent dynamics at the macromolecule-solvent interfaces as well as the perturbation effects caused by the water-macromolecule interactions on the solvent dynamical properties.
In this paper we demonstrate that Nuclear Magnetic Resonance Spectroscopy can be used to determine the dynamical contributions of proteins to the water molecules belonging to their hydration shells.
American Psychological Association (APA)
Martini, Silvia& Bonechi, Claudia& Foletti, Alberto& Rossi, Claudio. 2013. Water-Protein Interactions: The Secret of Protein Dynamics. The Scientific World Journal،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1011528
Modern Language Association (MLA)
Martini, Silvia…[et al.]. Water-Protein Interactions: The Secret of Protein Dynamics. The Scientific World Journal No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-1011528
American Medical Association (AMA)
Martini, Silvia& Bonechi, Claudia& Foletti, Alberto& Rossi, Claudio. Water-Protein Interactions: The Secret of Protein Dynamics. The Scientific World Journal. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1011528
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1011528