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Metabolic Disturbance in PCOS: Clinical and Molecular Effects on Skeletal Muscle Tissue
Joint Authors
Silva Dantas, Wagner
Gualano, Bruno
Patrocínio Rocha, Michele
Roberto Grimaldi Barcellos, Cristiano
dos Reis Vieira Yance, Viviane
Miguel Marcondes, José Antonio
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-05
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Polycystic ovary syndrome is a complex hormonal disorder affecting the reproductive and metabolic systems with signs and symptoms related to anovulation, infertility, menstrual irregularity and hirsutism.
Skeletal muscle plays a vital role in the peripheral glucose uptake.
Since PCOS is associated with defects in the activation and pancreatic dysfunction of β-cell insulin, it is important to understand the molecular mechanisms of insulin resistance in PCOS.
Studies of muscle tissue in patients with PCOS reveal defects in insulin signaling.
Muscle biopsies performed during euglycemic hyperinsulinemic clamp showed a significant reduction in glucose uptake, and insulin-mediated IRS-2 increased significantly in skeletal muscle.
It is recognized that the etiology of insulin resistance in PCOS is likely to be as complicated as in type 2 diabetes and it has an important role in metabolic and reproductive phenotypes of this syndrome.
Thus, further evidence regarding the effect of nonpharmacological approaches (e.g., physical exercise) in skeletal muscle of women with PCOS is required for a better therapeutic approach in the management of various metabolic and reproductive problems caused by this syndrome.
American Psychological Association (APA)
Silva Dantas, Wagner& Gualano, Bruno& Patrocínio Rocha, Michele& Roberto Grimaldi Barcellos, Cristiano& dos Reis Vieira Yance, Viviane& Miguel Marcondes, José Antonio. 2013. Metabolic Disturbance in PCOS: Clinical and Molecular Effects on Skeletal Muscle Tissue. The Scientific World Journal،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1011613
Modern Language Association (MLA)
Silva Dantas, Wagner…[et al.]. Metabolic Disturbance in PCOS: Clinical and Molecular Effects on Skeletal Muscle Tissue. The Scientific World Journal No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-1011613
American Medical Association (AMA)
Silva Dantas, Wagner& Gualano, Bruno& Patrocínio Rocha, Michele& Roberto Grimaldi Barcellos, Cristiano& dos Reis Vieira Yance, Viviane& Miguel Marcondes, José Antonio. Metabolic Disturbance in PCOS: Clinical and Molecular Effects on Skeletal Muscle Tissue. The Scientific World Journal. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1011613
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1011613