Blockage of Notch Signaling Inhibits the Migration and Proliferation of Retinal Pigment Epithelial Cells
Joint Authors
Liu, Weiwei
Jin, Guorong
Long, Chongde
Zhou, Xin
Tang, Yan
Huang, Shan
Kuang, Xielan
Wu, Lizi
Zhang, Qingjiong
Shen, Huangxuan
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-25
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
The Notch signaling is an evolutionarily conserved cell-cell communication pathway that plays critical roles in the proliferation, survival, apoptosis, and fate determination of mammalian cells.
Retinal pigment epithelial (RPE) cells are responsible for supporting the function of the neural retina and maintaining vision.
This study investigated the function of Notch signaling in RPE cells.
We found that the members of the Notch signaling pathway components were differentially expressed in RPE cells.
Furthermore, blockage of Notch signaling inhibited the migration and proliferation of RPE cells and reduced the expression levels of certain Notch signaling target genes, including HES1, MYC, HEY2, and SOX9.
Our data reveal a critical role of Notch signaling in RPE cells, suggesting that targeting Notch signaling may provide a novel approach for the treatment of ophthalmic diseases related to RPE cells.
American Psychological Association (APA)
Liu, Weiwei& Jin, Guorong& Long, Chongde& Zhou, Xin& Tang, Yan& Huang, Shan…[et al.]. 2013. Blockage of Notch Signaling Inhibits the Migration and Proliferation of Retinal Pigment Epithelial Cells. The Scientific World Journal،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1011615
Modern Language Association (MLA)
Liu, Weiwei…[et al.]. Blockage of Notch Signaling Inhibits the Migration and Proliferation of Retinal Pigment Epithelial Cells. The Scientific World Journal No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-1011615
American Medical Association (AMA)
Liu, Weiwei& Jin, Guorong& Long, Chongde& Zhou, Xin& Tang, Yan& Huang, Shan…[et al.]. Blockage of Notch Signaling Inhibits the Migration and Proliferation of Retinal Pigment Epithelial Cells. The Scientific World Journal. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1011615
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1011615