The Role of Thiamine Pyrophosphate in Prevention of Cisplatin Ototoxicity in an Animal Model
Joint Authors
Kuduban, Ozan
Kucur, Cuneyt
Sener, Ebru
Suleyman, Halis
Akcay, Fatih
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-16
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
The aim of this study was to evaluate the effectiveness of thiamine pyrophosphate against cisplatin-induced ototoxicity in guinea pigs.
Materials and Methods.
Healthy guinea pigs (n=18) were randomly divided into three groups.
Group 1 (n=6) received an intraperitoneal injection of saline solution and cisplatin for 7 days, group 2 (n=6) received an intraperitoneal injection of thiamine pyrophosphate and cisplatin for 7 days, and group 3 (n=6) received only intraperitoneal injection of saline for 7 days.
The animals in all groups were sacrificed under anesthesia, and their cochleas were harvested for morphological and biochemical observations.
Results.
In group 1, receiving only cisplatin, cochlear glutathione concentrations, superoxide dismutase, and glutathione peroxidase activities significantly decreased (P<0.05) and malondialdehyde concentrations significantly increased (P<0.05) compared to the control group.
In group 2, receiving thiamine pyrophosphate and cisplatin, the concentrations of enzymes were near those of the control group.
Microscopic examination showed that outer hair cells, spiral ganglion cells, and stria vascularis were preserved in group 2.
Conclusion.
Systemic administration of thiamine pyrophosphate yielded statistically significant protection to the cochlea of guinea pigs from cisplatin toxicity.
Further experimental animal studies are essential to determine the appropriate indications of thiamine pyrophosphate before clinical use.
American Psychological Association (APA)
Kuduban, Ozan& Kucur, Cuneyt& Sener, Ebru& Suleyman, Halis& Akcay, Fatih. 2013. The Role of Thiamine Pyrophosphate in Prevention of Cisplatin Ototoxicity in an Animal Model. The Scientific World Journal،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-1011626
Modern Language Association (MLA)
Kuduban, Ozan…[et al.]. The Role of Thiamine Pyrophosphate in Prevention of Cisplatin Ototoxicity in an Animal Model. The Scientific World Journal No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-1011626
American Medical Association (AMA)
Kuduban, Ozan& Kucur, Cuneyt& Sener, Ebru& Suleyman, Halis& Akcay, Fatih. The Role of Thiamine Pyrophosphate in Prevention of Cisplatin Ototoxicity in an Animal Model. The Scientific World Journal. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-1011626
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1011626