Tumor Necrosis Factor-Alpha Gene Promoter Region Polymorphism and the Risk of Coronary Heart Disease
Joint Authors
Asifa, Gul Zareen
Liaquat, Afrose
Murtaza, Iram
Kazmi, Syed Ali Raza
Javed, Qamar
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-05
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Tumor necrosis factor-alpha (TNF-α) gene polymorphisms have been implicated in the manifestation of atherosclerosis.
Controversy exists regarding the link between the cytokine’s variant genotype and CHD among different ethnic groups.
There have been fewer studies on the TNF-α gene −1031T>C and −863C>A polymorphisms in relation to CHD.
Therefore, the current study was designed to investigate the association of the TNF-α gene −1031T>C and −863C>A polymorphisms with CHD in a Pakistani population.
Methods.
Patients with CHD (n=310) and healthy individuals (n=310) were enrolled in this study.
Genotyping was performed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).
Results.
A significant difference was observed in the −863C>A polymorphism between patients with CHD and control subjects (P<0.0001).
CHD risk was positively associated with the variant allele −863A (P<0.0001) in the study subjects.
There was no significant link between the −1031T>C polymorphism and CHD risk in the study population.
Haplotypes A-T and A-C of the TNF-alpha gene loci at −863 and −1031 showed higher frequency in the patient group compared with controls (P<0.05).
Conclusion.
The TNF-α −863C>A gene polymorphism was associated with the pathogenesis of CHD while the −1031T>C polymorphism did not show any link with the disease in a Pakistani population.
American Psychological Association (APA)
Asifa, Gul Zareen& Liaquat, Afrose& Murtaza, Iram& Kazmi, Syed Ali Raza& Javed, Qamar. 2013. Tumor Necrosis Factor-Alpha Gene Promoter Region Polymorphism and the Risk of Coronary Heart Disease. The Scientific World Journal،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-1011670
Modern Language Association (MLA)
Asifa, Gul Zareen…[et al.]. Tumor Necrosis Factor-Alpha Gene Promoter Region Polymorphism and the Risk of Coronary Heart Disease. The Scientific World Journal No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-1011670
American Medical Association (AMA)
Asifa, Gul Zareen& Liaquat, Afrose& Murtaza, Iram& Kazmi, Syed Ali Raza& Javed, Qamar. Tumor Necrosis Factor-Alpha Gene Promoter Region Polymorphism and the Risk of Coronary Heart Disease. The Scientific World Journal. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-1011670
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1011670