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In Vitro Susceptibility of Candida Species to Four Antifungal Agents Assessed by the Reference Broth Microdilution Method
Joint Authors
Eksi, Fahriye
Gayyurhan, Efgan Dogan
Balci, Iclal
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-22
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
This study was performed to determine the distribution of Candida species isolated from the blood cultures of the patients hospitalized in our hospital and to investigate their antifungal susceptibility.
Candida strains were identified at species level by using classical methods and API ID 32C (bioMerieux, France) identification kits.
The susceptibility of the strains to amphotericin B, fluconazole, voriconazole, and caspofungin was evaluated by using the reference broth microdilution method in document M27-A3 of the Clinical and Laboratory Standards Institute.
Of the 111 Candida strains isolated, 47.7% were identified as C.
albicans and 52.3% as non-albicans Candida strains.
The MIC ranges were 0.03–1 μg/mL for amphotericin B, 0.125–≥64 μg/mL for fluconazole, 0.03–16 μg/mL for voriconazole, and 0.015–0.25 μg/mL for caspofungin.
All Candida strains were susceptible to amphotericin B and caspofungin.
10.8% isolates were resistant to fluconazole and 8.1% isolates were dose-dependent susceptible.
While 0.9% isolate was resistant to voriconazole, 0.9% isolate was dose-dependent susceptible.
In our study, C.
albicans and C.
parapsilosis were the most frequently encountered agents of candidemia and it was detected that voriconazole with a low resistance rate might also be used with confidence in the treatment of infections occurring with these agents, primarily besides amphotericin B and caspofungin.
American Psychological Association (APA)
Eksi, Fahriye& Gayyurhan, Efgan Dogan& Balci, Iclal. 2013. In Vitro Susceptibility of Candida Species to Four Antifungal Agents Assessed by the Reference Broth Microdilution Method. The Scientific World Journal،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1011745
Modern Language Association (MLA)
Eksi, Fahriye…[et al.]. In Vitro Susceptibility of Candida Species to Four Antifungal Agents Assessed by the Reference Broth Microdilution Method. The Scientific World Journal No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-1011745
American Medical Association (AMA)
Eksi, Fahriye& Gayyurhan, Efgan Dogan& Balci, Iclal. In Vitro Susceptibility of Candida Species to Four Antifungal Agents Assessed by the Reference Broth Microdilution Method. The Scientific World Journal. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1011745
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1011745