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On the Differential Diagnosis of Anxious from Nonanxious Major Depression by means of the Hamilton Scales
Joint Authors
Konstantakopoulos, George
Masdrakis, Vasilios G.
Markianos, Manolis
Oulis, Panagiotis
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-27
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Anxious major depressive disorder (A-MDD) is differentially diagnosed from nonanxious MDD (NA-MDD) as MDD with a cut-off score ≥7 on the HAM-D anxiety-somatization factor (ASF).
We investigated whether additional HAM-D items discriminate A-MDD from NA-MDD.
Moreover, we tested the validity of ASF criterion against HAM-A, gold standard of anxiety severity assessment.
Methods.
164 consecutive female middle-aged inpatients, diagnosed as A-MDD (n=92) or NA-MDD (n=72) by the normative HAM-A score for moderate-to-severe anxiety (≥25), were compared regarding 17-item HAM-D scores.
The validity of ASF ≥7 criterion was assessed by receiver-operating characteristics (ROC) analysis.
Results.
We found medium and large effect size differences between A-MDD and NA-MDD patients in only four out of the six ASF items, as well as in three further HAM-D items, namely, those of agitation, middle insomnia, and delayed insomnia.
Furthermore, the ASF cut-off score ≥9 provided the optimal trade-off between sensitivity and specificity for the differential diagnosis between A-MDD and NA-MDD.
Conclusion.
Additional HAM-D items, beyond those of ASF, discriminate A-MDD from NA-MDD.
The ASF ≥7 criterion inflates false positives.
A cut-off point ≥9 provides the best trade-off between sensitivity and specificity of the ASF criterion, at least in female middle-aged inpatients.
American Psychological Association (APA)
Konstantakopoulos, George& Masdrakis, Vasilios G.& Markianos, Manolis& Oulis, Panagiotis. 2013. On the Differential Diagnosis of Anxious from Nonanxious Major Depression by means of the Hamilton Scales. The Scientific World Journal،Vol. 2013, no. 2013, pp.1-4.
https://search.emarefa.net/detail/BIM-1011891
Modern Language Association (MLA)
Konstantakopoulos, George…[et al.]. On the Differential Diagnosis of Anxious from Nonanxious Major Depression by means of the Hamilton Scales. The Scientific World Journal No. 2013 (2013), pp.1-4.
https://search.emarefa.net/detail/BIM-1011891
American Medical Association (AMA)
Konstantakopoulos, George& Masdrakis, Vasilios G.& Markianos, Manolis& Oulis, Panagiotis. On the Differential Diagnosis of Anxious from Nonanxious Major Depression by means of the Hamilton Scales. The Scientific World Journal. 2013. Vol. 2013, no. 2013, pp.1-4.
https://search.emarefa.net/detail/BIM-1011891
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1011891