Preparation and Cyclodextrin Solubilization of the Antibacterial Agent Benzoyl Metronidazole
Joint Authors
Huang, Qing
Li, Benpeng
Yang, Shuo
Ma, Peipei
Wang, Zhizhong
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-21
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
A one-pot method for the preparation of benzoyl metronidazole was achieved by using N,N′-carbonyldiimidazole as a coupling reagent.
Moreover, it was found that the byproduct imidazole as the catalyst promoted the reaction.
In addition, the β-cyclodextrin solubilization of benzoyl metronidazole was investigated by phase-solubility method.
The phase-solubility studies indicated that the solubility of benzoyl metronidazole (S=0.1435 g/L) was substantially increased 9.7-fold (S′=1.3881 g/L) by formation of 1 : 1 benzoyl metronidazole/β-cyclodextrin complexes in water, and the association constant Ka value was determined to be 251 (±23) dm3/mol.
Therefore, β-cyclodextrin can work as a pharmaceutical solubilizer for benzoyl metronidazole and may improve its oral bioavailability.
American Psychological Association (APA)
Huang, Qing& Li, Benpeng& Yang, Shuo& Ma, Peipei& Wang, Zhizhong. 2013. Preparation and Cyclodextrin Solubilization of the Antibacterial Agent Benzoyl Metronidazole. The Scientific World Journal،Vol. 2013, no. 2013, pp.1-3.
https://search.emarefa.net/detail/BIM-1011923
Modern Language Association (MLA)
Huang, Qing…[et al.]. Preparation and Cyclodextrin Solubilization of the Antibacterial Agent Benzoyl Metronidazole. The Scientific World Journal No. 2013 (2013), pp.1-3.
https://search.emarefa.net/detail/BIM-1011923
American Medical Association (AMA)
Huang, Qing& Li, Benpeng& Yang, Shuo& Ma, Peipei& Wang, Zhizhong. Preparation and Cyclodextrin Solubilization of the Antibacterial Agent Benzoyl Metronidazole. The Scientific World Journal. 2013. Vol. 2013, no. 2013, pp.1-3.
https://search.emarefa.net/detail/BIM-1011923
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1011923