Chemically Cross-Linked Poly(acrylic-co-vinylsulfonic) Acid Hydrogel for the Delivery of Isosorbide Mononitrate
Joint Authors
Hussain, Talib
Ansari, Mahvash
Ranjha, Nazar Muhammad
Khan, Ikram Ullah
Shahzad, Yasser
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-23
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
We report synthesis, characterization, and drug release attributes of a series of novel pH-sensitive poly(acrylic-co-vinylsulfonic) acid hydrogels.
These hydrogels were prepared by employing free radical polymerization using ethylene glycol dimethacrylate (EGDMA) and benzyl peroxide (BPO) as cross-linker and initiator, respectively.
Effect of acrylic acid (AA), polyvinylsulfonic acid (PVSA), and EGDMA on prepared hydrogels was investigated.
All formulations showed higher swelling at high pHs and vice versa.
Formulations containing higher content of AA and EGDMA show reduced swelling, but one with higher content of PVSA showed increased swelling.
Hydrogel network was characterized by determining structural parameters and loaded with isosorbide mononitrate.
FTIR confirmed absence of drug polymer interaction while DSC and TGA demonstrated molecular dispersion of drug in a thermally stable polymeric network.
All the hydrogel formulations exhibited a pH dependent release of isosorbide mononitrate which was found to be directly proportional to pH of the medium and PVSA content and inversely proportional to the AA contents.
Drug release data were fitted to various kinetics models.
Results indicated that release of isosorbide mononitrate from poly(AA-co-VSA) hydrogels was non-Fickian and that the mechanism was diffusion-controlled.
American Psychological Association (APA)
Hussain, Talib& Ansari, Mahvash& Ranjha, Nazar Muhammad& Khan, Ikram Ullah& Shahzad, Yasser. 2013. Chemically Cross-Linked Poly(acrylic-co-vinylsulfonic) Acid Hydrogel for the Delivery of Isosorbide Mononitrate. The Scientific World Journal،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1011974
Modern Language Association (MLA)
Hussain, Talib…[et al.]. Chemically Cross-Linked Poly(acrylic-co-vinylsulfonic) Acid Hydrogel for the Delivery of Isosorbide Mononitrate. The Scientific World Journal No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-1011974
American Medical Association (AMA)
Hussain, Talib& Ansari, Mahvash& Ranjha, Nazar Muhammad& Khan, Ikram Ullah& Shahzad, Yasser. Chemically Cross-Linked Poly(acrylic-co-vinylsulfonic) Acid Hydrogel for the Delivery of Isosorbide Mononitrate. The Scientific World Journal. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1011974
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1011974