Polymorphisms but Not Mutations of the KCNQ1 Gene Are Associated with Lone Atrial Fibrillation in the Chinese Han Population
Joint Authors
Chu, Hui-min
Feng, Ming-jun
Li, Yi-gang
Zhang, Yi-xin
Ma, Ji-fang
He, Bin
Yu, Yi-bo
Liu, Jing
Chen, Xiao-min
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-18
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Recent studies suggest that mutation of the slow delayed rectifier potassium channel (IKs) contributes to familial atrial fibrillation (FAF).
In the current study, we identified common genetic variants of KCNQ1 and explored the potential association between KCNQ1 polymorphism with lone AF (LAF).
Methods.
Clinical data and blood samples were collected from 190 Han Chinese patients with sporadic AF and matched healthy controls.
Variants of the KCNQ1 gene were identified using single-strand conformational polymorphism (SSCP) analysis.
A case-control association study in KCNQ1 identified six known single-nucleotide polymorphisms (SNPs) during SSCP screening of the 190 LAF patients and 190 healthy controls.
Results.
One of the SNPs in KCNQ1 was strongly associated with LAF; significant allelic association was detected rs59233444 (P=0.013, OR=1.469, 95% confidence interval (CI): 1.083–1.993).
A multiple regression analysis indicated that rs59233444 is an independent risk factor for LAF.
Twelve new variants were identified in KCNQ1, including one in the 5′-UTR, two in the 3′-UTR, six in introns, two synonymous substitutions, and one missense substitution.
Variants c.1009C>T, c.1860C>T, and c.+2285C>T were not present in the 190 controls, and the others were identified in controls at various frequencies.
Conclusions.
rs59233444, a common SNP but not mutation in the coding regions of the KCNQ1 gene, is a risk factor for LAF in Chinese Han population.
American Psychological Association (APA)
Chu, Hui-min& Feng, Ming-jun& Li, Yi-gang& Zhang, Yi-xin& Ma, Ji-fang& He, Bin…[et al.]. 2013. Polymorphisms but Not Mutations of the KCNQ1 Gene Are Associated with Lone Atrial Fibrillation in the Chinese Han Population. The Scientific World Journal،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1012073
Modern Language Association (MLA)
Chu, Hui-min…[et al.]. Polymorphisms but Not Mutations of the KCNQ1 Gene Are Associated with Lone Atrial Fibrillation in the Chinese Han Population. The Scientific World Journal No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-1012073
American Medical Association (AMA)
Chu, Hui-min& Feng, Ming-jun& Li, Yi-gang& Zhang, Yi-xin& Ma, Ji-fang& He, Bin…[et al.]. Polymorphisms but Not Mutations of the KCNQ1 Gene Are Associated with Lone Atrial Fibrillation in the Chinese Han Population. The Scientific World Journal. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1012073
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1012073