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Gelatin-Modified Polyurethanes for Soft Tissue Scaffold
Joint Authors
Kucińska-Lipka, Justyna
Gubańska, Iga
Janik, Helena
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-20
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Recently, in the field of biomaterials for soft tissue scaffolds, the interest of their modification with natural polymersis growing.
Synthetic polymers are often tough, and many of them do not possess fine biocompatibility.
On the other hand, natural polymers are biocompatible but weak when used alone.
The combination of natural and synthetic polymers gives the suitable properties for tissue engineering requirements.
In our study, we modified gelatin synthetic polyurethanes prepared from polyester poly(ethylene-butylene adipate) (PEBA), aliphatic 1,6-hexamethylene diisocyanate (HDI), and two different chain extenders 1,4-butanediol (BDO) or 1-ethoxy-2-(2-hydroxyethoxy)ethanol (EHEE).
From a chemical point of view, we replaced expensive components for building PU, such as 2,6-diisocyanato methyl caproate (LDI) and 1,4-diisocyanatobutane (BDI), with cost-effective HDI.
The gelatin was added in situ (in the first step of synthesis) to polyurethane to increase biocompatibility and biodegradability of the obtained material.
It appeared that the obtained gelatin-modified PU foams, in which chain extender was BDO, had enhanced interactions with media and their hydrolytic degradation profile was also improved for tissue engineering application.
Furthermore, the gelatin introduction had positive impact on gelatin-modified PU foams by increasing their hemocompatibility.
American Psychological Association (APA)
Kucińska-Lipka, Justyna& Gubańska, Iga& Janik, Helena. 2013. Gelatin-Modified Polyurethanes for Soft Tissue Scaffold. The Scientific World Journal،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-1012306
Modern Language Association (MLA)
Kucińska-Lipka, Justyna…[et al.]. Gelatin-Modified Polyurethanes for Soft Tissue Scaffold. The Scientific World Journal No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-1012306
American Medical Association (AMA)
Kucińska-Lipka, Justyna& Gubańska, Iga& Janik, Helena. Gelatin-Modified Polyurethanes for Soft Tissue Scaffold. The Scientific World Journal. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-1012306
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1012306