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Chemical Constituents Antioxidant and Anticholinesterasic Activity of Tabernaemontana catharinensis
Joint Authors
Nicola, Carla
Salvador, Mirian
Escalona Gower, Adriana
Moura, Sidnei
Echeverrigaray, Sergio
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-25
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
The present work aimed to analyze the alkaloid content of the ethanolic extract of Tabernaemontana catharinensis (Apocynaceae family) and its fractions as well as to evaluate their antioxidant and anticholinesterasic activities.
The analyses of the ethanolic extract of T.
catharinensis by mass spectrometry allowed identifying the presence of the alkaloids 16-epi-affinine, coronaridine-hydroxyindolenine, voachalotine, voacristine-hydroxyindolenine, and 12-methoxy-n-methyl-voachalotine, as well as an alkaloid with m/z 385.21 whose spectrum suggests a derivative of voacristine or voacangine.
The extract and its alkaloid rich fractions showed antioxidant activity, especially those that contain the alkaloid m/z 385.21 or 16-epi-affinine with DPPH scavenging activity (IC50) between 37.18 and 74.69 μg/mL.
Moreover, the extract and its fractions exhibited anticholinesterasic activity, particularly the fractions characterized by the presence of 12-methoxy-n-methyl-voachalotine, with IC50 = 2.1 to 2.5 μg/mL.
Fractions with 16-epi-affinine combined good antioxidant (IC50 = 65.59 to 74.69 μg/mL) and anticholinesterasic (IC50 = 7.7 to 8.3 μg/mL) activities, representing an option for further studies aimed at treating neurodegenerative diseases.
American Psychological Association (APA)
Nicola, Carla& Salvador, Mirian& Escalona Gower, Adriana& Moura, Sidnei& Echeverrigaray, Sergio. 2013. Chemical Constituents Antioxidant and Anticholinesterasic Activity of Tabernaemontana catharinensis. The Scientific World Journal،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1012461
Modern Language Association (MLA)
Nicola, Carla…[et al.]. Chemical Constituents Antioxidant and Anticholinesterasic Activity of Tabernaemontana catharinensis. The Scientific World Journal No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-1012461
American Medical Association (AMA)
Nicola, Carla& Salvador, Mirian& Escalona Gower, Adriana& Moura, Sidnei& Echeverrigaray, Sergio. Chemical Constituents Antioxidant and Anticholinesterasic Activity of Tabernaemontana catharinensis. The Scientific World Journal. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1012461
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1012461