Association of Interleukin-6 Gene Promoter Polymorphism with Coronary Artery Disease in Pakistani Families

Abstract EN

Interleukin-6 (IL-6) is a well-known inflammatory cytokine and suggested to be involved in the development of coronary artery disease (CAD).

IL-6 gene expression has been investigated with controversy in CAD patients.

This study investigates the association of the IL-6 gene expression with CAD, the molecular basis for the regulation of interleukin-6 expression in a Pakistani population.

Our data show that the serum IL-6 levels were increased in patients with CAD compared with healthy controls and that the IL-6 gene polymorphism at -174 was more prevalent in CAD cases.

There was a statistically significant association between the IL-6 gene polymorphism and CAD, which may be associated with an increased risk for the disease.

Moreover, circulating IL-6 and hs-CRP levels were significantly higher in patients with CC genotype (P<0.0001 and P<0.0001, resp.).

In a binary logistic-regression model, an independent association was found between CAD and increased serum IL-6 and hs-CRP levels and -174G>C polymorphism.

This is the first report on the IL-6 expression and the IL-6 gene polymorphism in patients with CAD from Pakistan, and hence it highlights a novel risk factor for the disease.