Associates of an Elevated Natriuretic Peptide Level in Stable Heart Failure Patients: Implications for Targeted Management
Joint Authors
Jan, Aftab
Dawkins, Ian
Murphy, Niamh
Collier, Patrick
Baugh, John
Ledwidge, Mark
McDonald, Kenneth
Watson, Chris J.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-25
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Persistently elevated natriuretic peptide (NP) levels in heart failure (HF) patients are associated with impaired prognosis.
Recent work suggests that NP-guided therapy can improve outcome, but the mechanisms behind an elevated BNP remain unclear.
Among the potential stimuli for NP in clinically stable patients are persistent occult fluid overload, wall stress, inflammation, fibrosis, and ischemia.
The purpose of this study was to identify associates of B-type natriuretic peptide (BNP) in a stable HF population.
Methods.
In a prospective observational study of 179 stable HF patients, the association between BNP and markers of collagen metabolism, inflammation, and Doppler-echocardiographic parameters including left ventricular ejection fraction (LVEF), left atrial volume index (LAVI), and E/e prime (E/e′) was measured.
Results.
Univariable associates of elevated BNP were age, LVEF, LAVI, E/e′, creatinine, and markers of collagen turnover.
In a multiple linear regression model, age, creatinine, and LVEF remained significant associates of BNP.
E/e′ and markers of collagen turnover had a persistent impact on BNP independent of these covariates.
Conclusion.
Multiple variables are associated with persistently elevated BNP levels in stable HF patients.
Clarification of the relative importance of NP stimuli may help refine NP-guided therapy, potentially improving outcome for this at-risk population.
American Psychological Association (APA)
Jan, Aftab& Dawkins, Ian& Murphy, Niamh& Collier, Patrick& Baugh, John& Ledwidge, Mark…[et al.]. 2013. Associates of an Elevated Natriuretic Peptide Level in Stable Heart Failure Patients: Implications for Targeted Management. The Scientific World Journal،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1012520
Modern Language Association (MLA)
Jan, Aftab…[et al.]. Associates of an Elevated Natriuretic Peptide Level in Stable Heart Failure Patients: Implications for Targeted Management. The Scientific World Journal No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-1012520
American Medical Association (AMA)
Jan, Aftab& Dawkins, Ian& Murphy, Niamh& Collier, Patrick& Baugh, John& Ledwidge, Mark…[et al.]. Associates of an Elevated Natriuretic Peptide Level in Stable Heart Failure Patients: Implications for Targeted Management. The Scientific World Journal. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1012520
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1012520