Covalent Grafting of the RGD-Peptide onto Polyetheretherketone Surfaces via Schiff Base Formation
Joint Authors
Becker, Marc
Lorenz, Steffen
Strand, Dennis
Vahl, Christian-Friedrich
Gabriel, Matthias
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-21
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
In recent years, the synthetic polymer polyetheretherketone (PEEK) has increasingly been used in a number of orthopedic implementations, due to its excellent mechanical properties, bioinertness, and chemical resistance.
For in vivo applications, the surface of PEEK, which does not naturally support cell adhesion, has to be modified to improve tissue integration.
In the present work we demonstrate a novel wet-chemical modification of PEEK to modify the surface, enabling the covalent grafting of the cell-adhesive RGD-peptide.
Modification of the polymer surface was achieved via Schiff base formation using an aliphatic diamine and subsequent crosslinker-mediated immobilization of the peptide.
In cell culture experiments with primary osteoblasts it was shown that the RGD-modified PEEK not only significantly promoted cellular adhesion but also strongly enhanced the proliferation of osteoblasts on the modified polymer surface.
American Psychological Association (APA)
Becker, Marc& Lorenz, Steffen& Strand, Dennis& Vahl, Christian-Friedrich& Gabriel, Matthias. 2013. Covalent Grafting of the RGD-Peptide onto Polyetheretherketone Surfaces via Schiff Base Formation. The Scientific World Journal،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-1012613
Modern Language Association (MLA)
Becker, Marc…[et al.]. Covalent Grafting of the RGD-Peptide onto Polyetheretherketone Surfaces via Schiff Base Formation. The Scientific World Journal No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-1012613
American Medical Association (AMA)
Becker, Marc& Lorenz, Steffen& Strand, Dennis& Vahl, Christian-Friedrich& Gabriel, Matthias. Covalent Grafting of the RGD-Peptide onto Polyetheretherketone Surfaces via Schiff Base Formation. The Scientific World Journal. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-1012613
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1012613