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Muscle Wasting in Hemodialysis Patients: New Therapeutic Strategies for Resolving an Old Problem
Joint Authors
Chen, Chun-Ting
Lin, Shih-Hua
Chen, Jin-Shuen
Hsu, Yu-Juei
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-05
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Muscle wasting has long been recognized as a major clinical problem in hemodialysis (HD) patients.
In addition to its impact on quality of life, muscle wasting has been proven to be associated with increased mortality rates.
Identification of the molecular mechanisms underlying muscle wasting in HD patients provides opportunities to resolve this clinical problem.
Several signaling pathways and humeral factors have been reported to be involved in the pathogenic mechanisms of muscle wasting in HD patients, including ubiquitin-proteasome system, caspase-3, insulin/insulin-like growth factor-1 (IGF-1) signaling, endogenous glucocorticoids, metabolic acidosis, inflammation, and sex hormones.
Targeting the aforementioned crucial signaling and molecules to suppress protein degradation and augment muscle strength has been extensively investigated in HD patients.
In addition to exercise training, administration of megestrol acetate has been proven to be effective in improving anorexia and muscle wasting in HD patients.
Correction of metabolic acidosis through sodium bicarbonate supplements can decrease muscle protein degradation and hormone therapy with nandrolone decanoate has been reported to increase muscle mass.
Although thiazolidinedione has been shown to improve insulin sensitivity, its role in the treatment of muscle wasting remains unclear.
This review paper focuses on the molecular pathways and potential new therapeutic approaches to muscle wasting in HD patients.
American Psychological Association (APA)
Chen, Chun-Ting& Lin, Shih-Hua& Chen, Jin-Shuen& Hsu, Yu-Juei. 2013. Muscle Wasting in Hemodialysis Patients: New Therapeutic Strategies for Resolving an Old Problem. The Scientific World Journal،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1012667
Modern Language Association (MLA)
Chen, Chun-Ting…[et al.]. Muscle Wasting in Hemodialysis Patients: New Therapeutic Strategies for Resolving an Old Problem. The Scientific World Journal No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-1012667
American Medical Association (AMA)
Chen, Chun-Ting& Lin, Shih-Hua& Chen, Jin-Shuen& Hsu, Yu-Juei. Muscle Wasting in Hemodialysis Patients: New Therapeutic Strategies for Resolving an Old Problem. The Scientific World Journal. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1012667
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1012667