Targeting the B-Cell Pathway in Lupus Nephritis: Current Evidence and Future Perspectives
Joint Authors
Pyrpasopoulou, Athina
Pateinakis, Panagiotis
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-26
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Nephritis represents a frequent, severe complication of systemic lupus erythematosus.
Autoantibodies appear to be fundamental in the pathogenesis of lupus nephritis.
Several hypotheses are currently experimentally tested to further elucidate the direct induction of inflammation through interaction of the pathological autoantibodies with intrinsic glomerular components and the triggering of a complement-driven autoinflammatory cascade.
B-cells have, in the last decade, emerged as a promising new therapeutic target, as biological treatments successfully attempting B-cell depletion, inhibition of B-cell proliferation and differentiation, or modulation of B-cell function have become bioengineered.
Clinical trials have so far proved controversial regarding the efficacy of these new agents.
Thus, despite the short and long-term side effects associated with immunosuppressive treatment alternative emerging treatments are still regarded “rescue” regimens in refractory patients.
In an effort to accurately evaluate the potential of these therapies in lupus nephritis, several issues have been raised mainly in terms of patient selection criteria and trial duration.
This review aims to expand on the proposed pathophysiologic mechanisms implicating the B-cell pathway in the pathogenesis of lupus nephritis and summarize current knowledge obtained from clinical trials introducing these biologics in its treatment.
Finally, it will elaborate on potential applications of currently available biologic agents and forthcoming treatment options.
American Psychological Association (APA)
Pateinakis, Panagiotis& Pyrpasopoulou, Athina. 2013. Targeting the B-Cell Pathway in Lupus Nephritis: Current Evidence and Future Perspectives. The Scientific World Journal،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-1012825
Modern Language Association (MLA)
Pateinakis, Panagiotis& Pyrpasopoulou, Athina. Targeting the B-Cell Pathway in Lupus Nephritis: Current Evidence and Future Perspectives. The Scientific World Journal No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-1012825
American Medical Association (AMA)
Pateinakis, Panagiotis& Pyrpasopoulou, Athina. Targeting the B-Cell Pathway in Lupus Nephritis: Current Evidence and Future Perspectives. The Scientific World Journal. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-1012825
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1012825